Abstract
The design of functional polymer multilayer thin films with nanometer scale control is of great interest for biomedical applications such as tissue engineering, targeted drug delivery, controlled release system, and regenerative medicine. Various functions and properties of polymer thin films can be easily programmed and realized by the layer-by-layer assembly strategy, which is a facile and versatile deposition method to prepare well-defined biomedical multilayer platforms due to its benign process to prepare films under mild conditions and the capability of incorporating bioactive materials at a desired location within the films. Particularly, the fine tuning of physicochemical and biological properties of multilayer thin films is significantly important for designing novel biomedical platforms capable of adjusting the cellular functions. In this review, we focus on the overall background of the layer-by-layer assembly as well as the tuning of multilayer film properties and the programming of biological functions into the polymer thin films with a view on the control of cellular functions. Furthermore, we highlighted the recent achievements toward the design of novel biomedical platforms based on functionalized polymer multilayer thin films.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
G. Decher, Science, 277, 1232 (1997).
G. Decher and J. D. Hong, Makromolekulare Chemie-Macromolecular Symposia, 46, 321 (1991).
P. T. Hammond, Adv. Mater., 16, 1271 (2004).
J. A. Jaber and J. B. Schlenoff, Current Opinion in Colloid Interf. Sci., 11, 324 (2006).
Z. Tang, Y. Wang, P. Podsiadlo and N. A. Kotov, Adv. Mater., 18, 3203 (2006).
C.Y. Jiang and V.V. Tsukruk, Adv. Mater., 18, 829 (2006).
A. Quinn, G. K. Such, J. F. Quinn and F. Caruso, Adv. Funct. Mater., 18, 17 (2008).
Y. Wang, A. S. Angelatos and F. Caruso, Chem. Mater., 20, 848 (2008).
E. Kharlampieva, V. Kozlovskaya and S. A. Sukhishvili, Adv. Mater., 21, 3053 (2009).
J. B. Schlenoff, Langmuir, 25, 14007 (2009).
R.K. Iler, J. Colloid Interf. Sci., 21, 569 (1966).
J. Cho, K. Char, J.D. Hong and K. B. Lee, Adv. Mater., 13, 1076 (2001).
J. B. Schlenoff, S. T. Dubas and T. Farhat, Langmuir, 16, 9968 (2000).
M. Lee, W. Park, C. Chung, J. Lim, S. Kwon, K. H. Ahn, S. J. Lee and K. Char, Lab on a Chip, 10, 1160 (2010).
T. Boudou, T. Crouzier, K. F. Ren, G. Blin and C. Picart, Adv. Mater., 22, 441 (2010).
R. von Klitzing, Phys. Chem. Chem. Phys., 8, 5012 (2006).
J. Seo, H. Lee, J. Jeon, Y. Jang, R. Kim, K. Char and J. M. Nam, Biomacromolecules, 10, 2254 (2009).
D. E. Discher, P. Janmey and Y. L. Wang, Science, 310, 1139 (2005).
S. S. Shiratori and M. F. Rubner, Macromolecules, 33, 4213 (2000).
J. Hiller and M. F. Rubner, Macromolecules, 36, 4078 (2003).
J. D. Mendelsohn, S.Y. Yang, J. Hiller, A. I. Hochbaum and M. F. Rubner, Biomacromolecules, 4, 96 (2003).
S. T. Dubas and J. B. Schlenoff, Langmuir, 17, 7725 (2001).
H.W. Jomaa and J. B. Schlenoff, Macromolecules, 38, 8473 (2005).
A. Fery, B. Scholer, T. Cassagneau and F. Caruso, Langmuir, 17, 3779 (2001).
C. Picart, A. Schneider, O. Etienne, J. Mutterer, P. Schaaf, C. Egles, N. Jessel and J. C. Voegel, Adv. Funct. Mater., 15, 1771 (2005).
B. S. Kim, S.W. Park and P. T. Hammond, Acs Nano, 2, 386 (2008).
Y. Itoh, M. Matsusaki, T. Kida and M. Akashi, Biomacromolecules, 9, 2202 (2008).
S. A. Sukhishvili, Current Opinion in Colloid Interf. Sci., 10, 37 (2005).
J. F. Quinn and F. Caruso, Langmuir, 20, 20 (2004).
D.V. Volodkin, N. Madaboosi, J. Blacklock, A.G. Skirtach and H. Mohwald, Langmuir, 25, 14037 (2009).
T. Serizawa, M. Yamaguchi and M. Akashi, Angewandte Chemie-International Edition, 42, 1115 (2003).
K. C. Wood, J. Q. Boedicker, D. M. Lynn and P. T. Hammon, Langmuir, 21, 1603 (2005).
K. C. Wood, H. F. Chuang, R. D. Batten, D. M. Lynn and P. T. Hammond, Proceedings of the National Academy of Sciences of the United States of America, 103, 10207 (2006).
A. P. Ngankam, G. Z. Mao and P. R. Van Tassel, Langmuir, 20, 3362 (2004).
S.G. Olenych, M.D. Moussallem, D. S. Salloum, J. B. Schlenoff and T. C. S. Keller, Biomacromolecules, 6, 3252 (2005).
C. Picart, R. Elkaim, L. Richert, T. Audoin, Y. Arntz, M. D. Cardoso, P. Schaaf, J. C. Voegel and B. Frisch, Adv. Funct. Mater., 15, 83 (2005).
D. L. Elbert, C. B. Herbert and J. A. Hubbell, Langmuir, 15, 5355 (1999).
O. Etienne, C. Gasnier, C. Taddei, J. C. Voegel, D. Aunis, P. Schaaf, M. H. Metz-Boutigue, A. L. Bolcato-Bellemin and C. Egles, Biomaterials, 26, 6704 (2005).
J. Klages, A. Kotzsch, M. Coles, W. Sebald, J. Nickel, T. Mueller and H. Kessler, Biochemistry, 47, 11930 (2008).
C. Ditzen, J. Varadarajulu, L. Czibere, M. Gonik, B. S. Targosz, B. Hambsch, T. Bettecken, M. S. Kessler, E. Frank, M. Bunck, L. Teplytska, A. Erhardt, F. Holsboer, B. Mueller-Myhsok, R. Landgraf and C.W. Turck, Molecular Psychiatry, 15, 702 (2010).
Y. Liu, T. He, C. Gao and J. Rassow, Coll. Surf. B: Biointerfaces, 46, 117 (2005).
M. Mueller, B. Kessler and W. Ouyang, Zeitschrift Fur Physikalische Chemie-International Journal of Research in Phys. Chem. Chem. Phys., 221, 127 (2007).
J. Zhang, B. Senger, D. Vautier, C. Picart, P. Schaaf, J. Voegel and P. Lavalle, Biomaterials, 26, 3353 (2005).
Y. Ikada, Biomaterials, 15, 725 (1994).
Y. B. Zhu, C.Y. Gao and J. C. Shen, Biomaterials, 23, 4889 (2002).
B. E. Jarrell, S.K. Williams, G. Stokes, F. A. Hubbard, R. A. Carabasi, E. Koolpe, D. Greener, K. Pratt, M. J. Moritz, J. Radomski and L. Speicher, Surgery, 100, 392 (1986).
T. I. Croll, A. J. O’Connor, G.W. Stevens and J. J. Cooper-White, Biomacromolecules, 7, 1610 (2006).
M. R. Doran, J. E. Frith, A. B. J. Prowse, J. Fitzpatrick, E. J. Wolvetang, T. P. Munro, P. P. Gray and J. J. Cooper-White, Biomaterials, 31, 5137 (2010).
E. K. F. Yim, E. M. Darling, K. Kulangara, F. Guilak and K.W. Leong, Biomaterials, 31, 1299 (2010).
L. Yang, B.W. Sheldon and T. J. Webster, J. Biomedical Mater. Res. Part A, 91A, 548 (2009).
D. S. Kommireddy, S. M. Sriram, Y. M. Lvov and D. K. Mills, Biomaterials, 27, 4296 (2006).
E. Jan and N. A. Kotov, Nano Lett., 7, 1123 (2007).
M. C. Berg, S.Y. Yang, P. T. Hammond and M. F. Rubner, Langmuir, 20, 1362 (2004).
A. Khademhosseini, K.Y. Suh, J. M. Yang, G. Eng, J. Yeh, S. Levenberg and R. Langer, Biomaterials, 25, 3583 (2004).
C. Boura, S. Muller, D. Vautier, D. Dumas, P. Schaaf, J. C. Voegel, J. F. Stoltz and P. Menu, Biomaterials, 26, 4568 (2005).
N. B. Jessel, P. Schwinte, R. Donohue, P. Lavalle, F. Boulmedais, R. Darcy, B. Szalontai, J. C. Voegel and J. Ogier, Adv. Funct. Mater., 14, 963 (2004).
J. Chluba, J. C. Voegel, G. Decher, P. Erbacher, P. Schaaf and J. Ogier, Biomacromolecules, 2, 800 (2001).
F. Rehfeldt, A. J. Engler, A. Eckhardt, F. Ahmed and D. E. Diseher, Advanced Drug Delivery Reviews, 59, 1329 (2007).
C. P. Vazquez, T. Boudou, V. Dulong, C. Nicolas, C. Picart and K. Glinel, Langmuir, 25, 3556 (2009).
J. Blacklock, A. Vetter, A. Lankenau, D. Oupicky and H. Mohwald, Biomaterials, 31, 7167 (2010).
D. S. Salloum, S.G. Olenych, T. C. S. Keller and J. B. Schlenoff, Biomacromolecules, 6, 161 (2005).
M. T. Thompson, M. C. Berg, I. S. Tobias, M. F. Rubner and K. J. Van Vliet, Biomaterials, 26, 6836 (2005).
A. Schneider, G. Francius, R. Obeid, P. Schwinte, J. Hemmerle, B. Frisch, P. Schaaf, J. C. Voegel, B. Senger and C. Picart, Langmuir, 22, 1193 (2006).
C. R. Wittmer, J. A. Phelps, W. M. Saltzman and P. R. Van Tassel, Biomaterials, 28, 851 (2007).
C. Dani, A.G. Smith, S. Dessolin, P. Leroy, L. Staccini, P. Villageois, C. Darimont and G. Ailhaud, J. Cell Sci., 110, 1279 (1997).
S. Okabe, K. ForsbergNilsson, A. C. Spiro, M. Segal and R. D. G. McKay, Mechanisms of Development, 59, 89 (1996).
B. Soria, A. Skoudy and F. Martin, Diabetologia, 44, 407 (2001).
A. M. Wobus, G. Wallukat and J. Hescheler, Differentiation, 48, 173 (1991).
A. Dierich, E. Le Guen, N. Messaddeq, J. F. Stoltz, P. Netter, P. Schaaf, J. C. Voegel and N. Benkirane-Jessel, Adv. Mater., 19, 693 (2007).
A. Nadiri, S. Kuchler-Bopp, H. Mjahed, B. Hu, Y. Haikel, P. Schaaf, J. C. Voegel and N. Benkirane-Jessel, Small, 3, 1577 (2007).
M.A. Wozniak, R. Desai, P.A. Solski, C. J. Der and P. J. Keely, J. Cell Biology, 163, 583 (2003).
A. J. Engler, S. Sen, H. L. Sweeney and D. E. Discher, Cell, 126, 677 (2006).
K. F. Ren, T. Crouzier, C. Roy and C. Picart, Adv. Funct. Mater., 18, 1378 (2008).
B. Neu, A. Voigt, R. Mitlohner, S. Leporatti, C.Y. Gao, E. Donath, H. Kiesewetter, H. Mohwald, H. J. Meiselman and H. Baumler, J. Microencapsulation, 18, 385 (2001).
H. Ai, M. Fang, S.A. Jones and Y. M. Lvov, Biomacromolecules, 3, 560 (2002).
B. Wang, P. Liu, W.G. Jiang, H. H. Pan, X. R. Xu and R. K. Tang, Angewandte Chemie-International Edition, 47, 3560 (2008).
A. L. Hillberg and M. Tabrizian, Biomacromolecules, 7, 2742 (2006).
J. T. Wilson, W.X. Cui and E. L. Chaikof, Nano Lett., 8, 1940 (2008).
M. Matsusaki, K. Kadowaki, Y. Nakahara and M. Akashi, Angew. Chem. Inter. Ed., 46, 4689 (2007).
K. Kadowaki, M. Matsusaki and M. Akashi, Langmuir, 26, 5670 (2010).
A. Guyomard, E. De, T. Jouenne, J. J. Malandain, G. Muller and K. Glinel, Adv. Funct. Mater., 18, 758 (2008).
D. Lee, R. E. Cohen and M. F. Rubner, Langmuir, 21, 9651 (2005).
T. Serizawa, M. Yamaguchi and M. Akashi, Biomacromolecules, 3, 724 (2002).
B. Thierry, F. M. Winnik, Y. Merhi, J. Silver and M. Tabrizian, Biomacromolecules, 4, 1564 (2003).
F. Yamauchi, K. Kato and H. Iwata, Langmuir, 21, 8360 (2005).
D. Lynn, Adv. Mater., 19, 4118 (2007).
C. M. Jewell and D. M. Lynn, Advanced Drug Delivery Reviews, 60, 979 (2008).
S. Levenberg, N. F. Huang, E. Lavik, A. B. Rogers, J. Itskovitz-Eldor and R. Langer, Proceedings of the National Academy of Sciences of the United States of America, 100, 12741 (2003).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jang, Y., Park, S. & Char, K. Functionalization of polymer multilayer thin films for novel biomedical applications. Korean J. Chem. Eng. 28, 1149–1160 (2011). https://doi.org/10.1007/s11814-010-0434-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11814-010-0434-x