Abstract
Rapid expansion of supercritical solution (RESS) was used for preparing polymer particles and polymer coating of ultra fine powders. The polymer of pharmaceutical interest was Poly(lactic-co-glycolic acid) (PLGA with PLA: PGA ratio of 85: 15 and MW of 50,000–75,000) and the simulated core particles were 1.4-μm SiO2 and 70-nm TiO2 particles. The supercritical solution was prepared by dissolving PLGA in supercritical carbon dioxide with ethanol as a cosolvent. Supercritical solution of CO2-PLGA was sprayed through capillary nozzles to ambient conditions, resulting in formation of submicron PLGA particles. Similarly, rapid expansion of supercritical solution of CO2-PLGA suspended with the core particles could provide solvent evaporation and deposition of submicron PLGA particles on the surface of the core particles, resulting in the formation of coating films on dispersed particles of SiO2 and agglomerates of TiO2. The influences of the core particle size, spray nozzle diameter as well as powder-to-polymer weight ratio were also investigated and discussed with respect to the coating performance.
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Kongsombut, B., Chen, W., Tsutsumi, A. et al. Formation of deagglomerated PLGA particles and PLGA-coated ultra fine powders by rapid expansion of supercritical solution with ethanol cosolvent. Korean J. Chem. Eng. 25, 838–845 (2008). https://doi.org/10.1007/s11814-008-0139-6
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DOI: https://doi.org/10.1007/s11814-008-0139-6