Abstract
Objective
To observe the clinical efficacy of acupuncture and moxibustion for functional dyspepsia (FD) due to Yang deficiency of the spleen and stomach.
Methods
A total of 90 patients meeting the inclusion criteria of FD due to Yang deficiency of the spleen and stomach were randomized into an acupuncture-moxibustion group, an electroacupuncture (EA) group, and a mosapride group by the random number table method, with 30 cases in each group. The mosapride group was treated with mosapride citrate dispersible tablets. The EA group was treated with EA treatment. The acupuncture-moxibustion group was treated with additional moxibustion therapy based on the treatment in the EA group. All three groups took 10 d as one treatment course and 2 courses in total, with a 2-day interval between two courses. The traditional Chinese medicine (TCM) symptoms score, functional digestive disorder quality of life questionnaire (FDDQL) score, oral-colon transit time (OCTT), and serum glucagon-like peptide-1 (GLP-1) level was compared before and after treatment among the three groups. And the clinical efficacy was evaluated.
Results
The total effective rate in the acupuncture-moxibustion group was 96.7%, which was higher than 86.7% in the EA group and 73.3% in the mosapride group, and the total effective rate in the EA group was higher than that in the mosapride group; the inter-group differences were all statistically significant (P<0.05). After treatment, the TCM symptom score in the three groups was lower than that before treatment (P<0.05), and the FDDQL score was higher than that before treatment (P<0.05). The change after treatment in the TCM symptom score in the acupuncture-moxibustion group and the EA group was more significant than that in the mosapride group, and the change in the acupuncture-moxibustion group was more significant than that in the EA group; the inter-group differences were statistically significant (P<0.05). The change after treatment in the FDDQL score in the acupuncture-moxibustion group and the EA group was greater than that in the mosapride group, and the change in the acupuncture-moxibustion group was larger than that in the EA group; the inter-group differences were all statistically significant (P<0.05). After treatment, the OCTT in all three groups was lower than that before treatment (P<0.05), and the serum GLP-1 level was higher than that before treatment (P<0.05); the change after treatment in the OCTT in the acupuncture-moxibustion group and the EA group was more significant than that in the mosapride group, and the change in the acupuncture-moxibustion group was more significant than that in the EA group; the inter-group differences were statistically significant (P<0.05). The change after treatment in the serum GLP-1 level in the acupuncture-moxibustion group and the EA group was greater than that in the mosapride group, and the change in the acupuncture-moxibustion group was larger than that in the EA group; the inter-group differences were statistically significant (P<0.05).
Conclusion
Acupuncture and moxibustion can improve the clinical symptoms in patients with FD and enhance their quality of life, producing better effects than EA or mosapride alone. Shortening gastrointestinal movement time and increasing gastrointestinal hormone levels may be its mechanism.
摘要
目的
观察针灸治疗脾胃阳虚型功能性消化不良(FD)的临床疗效。
方法
将90例符合脾胃阳虚型FD纳入标准 的患者按随机数字表法分为针灸组、电针组和莫沙比利组, 每组30例。莫沙比利组予枸橼酸莫沙比利分散片治疗, 电 针组予电针治疗, 针灸组在电针组的基础上加灸法治疗。三组均以10 d为1个疗程, 治疗2个疗程, 疗程间休息2 d。 比较三组患者治疗前后中医症状评分、功能性消化不良生活质量问卷(FDDQL)评分、口-结肠转运时间(OCTT)及血清 胰高血糖素样肽-1 (GLP-1)水平, 并评价临床疗效。
结果
针灸组的总有效率为96.7%, 高于电针组的86.7%和莫沙比利 组的73.3%, 且电针组总有效率高于莫沙比利组; 组间差异均有统计学意义(P<0.05)。治疗后三组患者中医症状评分低 于本组治疗前(P<0.05), FDDQL评分高于本组治疗前(P<0.05)。针灸组和电针组治疗后中医症状评分变化较莫沙比利组 显著, 针灸组变化较电针组显著; 组间差异均有统计学意义(P<0.05)。针灸组和电针组FDDQL评分治疗后变化大于莫 沙比利组, 针灸组变化大于电针组; 组间差异均有统计学意义(P<0.05)。治疗后三组患者OCTT低于本组治疗前 (P<0.05), 血清GLP-1水平高于本组治疗前(P<0.05); 针灸组和电针组治疗后OCTT变化较莫沙比利组显著, 针灸组变化 较电针组显著; 组间差异均有统计学意义(P<0.05)。针灸组和电针组治疗后血清GLP-1变化大于莫沙比利组, 针灸组变 化大于电针组; 组间差异均有统计学意义(P<0.05)。
结论
针灸可改善FD患者的临床症状, 提高其生活质量, 效果优于 电针或莫沙比利单独治疗; 缩短胃肠运动时间, 提高胃肠激素水平可能是其作用机理。
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Acknowledgments
This work was supported by the Project of Hunan Provincial Natural Science Foundation of China (湖南省自 然科学基金项目, No. 2022JJ40301); Fund Project of Hunan Province Education Office (湖南省教育厅科学研 究项目, No. 21B0369); Scientific Fund Project of Hunan University of Chinese Medicine (湖南中医药大学科研基 金项目, No. 2021XJJJ013).
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First Author: LIU Yan, bachelor, attending physician
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Liu, Y., Zhang, S., Ding, Y. et al. Clinical observation of acupuncture and moxibustion for functional dyspepsia due to Yang deficiency of the spleen and stomach. J. Acupunct. Tuina. Sci. 20, 470–475 (2022). https://doi.org/10.1007/s11726-022-1347-z
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DOI: https://doi.org/10.1007/s11726-022-1347-z
Keywords
- Acupuncture-moxibustion Therapy
- Acupuncture Therapy
- Electroacupuncture
- Thermal Box Moxibustion
- Dyspepsia
- Quality of Life
- Yang Deficiency of the Spleen and Stomach Pattern