Abstract
The Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was identified in December 2019. The symptoms include fever, cough, dyspnea, early symptom of sputum, and acute respiratory distress syndrome (ARDS). Mesenchymal stem cell (MSC) therapy is the immediate treatment used for patients with severe cases of COVID-19. Herein, we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19. MSC transplantation increases the immune indicators (including CD4 and lymphocytes) and decreases the inflammation indicators (interleukin-6 and C-reactive protein). High-flow nasal cannula can be used as an initial support strategy for patients with ARDS. With MSC transplantation, the fraction of inspired O2 (FiO2) of the two patients gradually decreased while the oxygen saturation (SaO2) and partial pressure of oxygen (PO2) improved. Additionally, the patients’ chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion. Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19, particularly in patients with ARDS.
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Acknowledgements
The authors thank Dr. Shusen Zheng and Dr. Tingbo Liang from The First Affiliated Hospital, College of Medicine, Zhejiang University for support of this work. This work was supported by the Technological Special Project for Significant New Drugs Development of China (No. 2018ZX09201002-005) and National Key R&D Program of China (No. 2017YFA0105701), the National Science and Technology Major Project (No. 2017ZX10204401), and the Emergency Research Fund for COVID-19 of Zhejiang Province (No. 2020C03125).
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Lingling Tang, Yingan Jiang, Mengfei Zhu, Lijun Chen, Xiaoyang Zhou, Chenliang Zhou, Peng Ye, Xiaobei Chen, Baohong Wang, Zhenyu Xu, Qiang Zhang, Xiaowei Xu, Hainv Gao, Xiaojun Wu, Dong Li, Wanli Jiang, Jingjing Qu, Charlie Xiang, and Lanjuan Li declare no conflicts of interest. This study was approved by the Ethics Committee of Shulan (Hangzhou) hospital, Hangzhou, China and the Ethics Committee of Renmin Hospital of Wuhan University (No. WDRY2020-K011), Wuhan, China. MSC administration in patients with SARS-CoV-2 induced ARDS was conducted in a multi-center and open-label clinical trial (No. ChiCTR2000029606).
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Tang, L., Jiang, Y., Zhu, M. et al. Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19. Front. Med. 14, 664–673 (2020). https://doi.org/10.1007/s11684-020-0810-9
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DOI: https://doi.org/10.1007/s11684-020-0810-9