Abstract
The vital utilization of biosensors in different domains has led to the design of much more precise and powerful biosensors, since they have the potential to attain information in a fast and simple manner compared to conventional assays. The present review describes the basic concepts, operation, and construction of biosensors and presented an ideology that choice of categorization, selection of immobilization method and advantages are crucial factors for an efficient and commercial biosensor. Amongst various biosensors, the field effect transistor (FET)-based biosensors have shown much more potential and immense advantages such as high detection ability and sensitivity for both neutral and charged biomolecules and, hence, have been explored comprehensively in the present review. This paper discusses the current challenges in device design by mainly focusing on the quantitative and qualitative performance parameters such as sensing surface properties, signal-to-noise ratio and various other factors, since consideration of these factors will eventually address the crucial concerns related to device design and practical limitations. The critical measures to translate the commercialization of biosensors in the market at a high pace have also been discussed. Hence, the discussion on device challenges illustrates that there is a scope of improvement in the areas such as short-channel effects, specificity and nanocavity filling factor for revolutionary advances in FET-based biosensors. Optimal selection of design rules and biosensing material has the potential to feature the next generation of biosensors. The present paper reports that following integrated multidisciplinary approaches and switching to nanotechnology in designing of FET-based biosensors can offer a lot of improvements in the practical key factors (such as low cost and reliability) and opportunities for the biosensors in the marketplace.
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C.L. Clark Jr, and C. Lyons, Ann. N.Y. Acad. Sci. 102, 29 (1962).
P. Mehrotra, J. Oral Biol. Craniofac. Res. 6, 153 (2016).
S. Patel, R. Nanda, S. Sahoo, and E. Mohapatra, Biochem. Res. Int., 3130469 (2016).
J.C. Dutta and S. Roy, Am. J. Biomed. Sci. 3, 176 (2011).
B.N. Giepmans, S.R. Adams, M.H. Ellisman, and R.Y. Tsien, Science 312, 217 (2006).
C.S. Pundir, S. Lata, and V. Narwal, Biosens. Bioelectron. 117, 373 (2018).
S.K. Arya, A. Chaubey, and B.D. Malhotra, Proc. Indian Natl. Sci. Acad. 72, 249 (2006).
S. Cheng, K. Hotani, S. Hideshima, S. Kuroiwa, T. Nakanishi, M. Hashimoto, and T. Osaka, Materials 7, 2490 (2014).
H. Du, C.M. Strohsahl, J. Camera, B.L. Miller, and T.D. Krauss, J. Am. Chem. Soc. 127, 7932 (2005).
A. Hasan, M. Nurunnabi, M. Morshed, A. Paul, A. Polini, T. Kuila, and A. A. Jaffa, BioMed. Res. Int. 2014, 18 (2014).
P. Damborský, J. Švitel, and J. Katrlík, Essays Biochem. 60, 91 (2016).
T. Osaka, M. Datta, and Y. Shacham-Diamand, SSBM (2009).
A. Syahir, K. Usui, K.Y. Tomizaki, K. Kajikawa, and H. Mihara, Microarrays 4, 228 (2015).
D.A. Hall, J. Ptacek, and M. Snyder, Mech. Ageing Dev. 128, 161 (2007).
S. Ray, G. Mehta, and S. Srivastava, Proteomics 10, 731 (2010).
E. Stern, A. Vacic, N.K. Rajan, J.M. Criscione, J. Park, B.R. Ilic, and T.M. Fahmy, Nat. Nanotechnol. 5, 138 (2010).
A. Sassolas, L.J. Blum, and B.D. Leca-Bouvier, Biotechnol. Adv. 30, 489 (2012).
C. Liu, C. Xu, N. Xue, J.H. Sun, H. Cai, T. Li, and J. Wang, MEMS Sensors-Design and Application, ed. S. Yellampalli (Rijeka: IntechOpen, 2018), p. 49.
R. Halai and M. Cooper, Label-Free Biosensor Methods in Drug Discovery, ed. Y. Fang (New York, NY: Humana Press, 2015), p. 3.
A. Poghossian and M.J. Schöning, Electroanalysis 26, 1197 (2014).
J. Haccoun, B. Piro, V. Noel, and M.C. Pham, Bioelectrochemistry 68, 218 (2006).
S. Singh, P.R. Solanki, M.K. Pandey, and B.D. Malhotra, Sensors Actuat. B: Chem. 115, 534 (2006).
S.K. Sharma, R. Singhal, B.D. Malhotra, N. Sehgal, and A. Kumar, Biotechnol. Lett. 26, 645 (2004).
S. Datta, L.R. Christena, and Y.R.S. Rajaram, Biotech 3, 7932 (2013).
B. Brena, P. González-Pombo, and F. Batista-Viera, Immobilization of Enzymes and Cells, ed. J.M. Guisan (Totowa, NJ: Humana Press, 2013), p. 15.
Y.C. Syu, W.E. Hsu, and C.T. Lin, ECS J. Solid State Sci. Technol. 7, Q3196 (2018).
S. M. Sze, and K.K. Ng, (Wiley, 2006).
M. Kaisti, Biosens. Bioelectron. 98, 437 (2017).
K. Shoorideh and C.O. Chui, IEEE Trans. Electron. Dev. 59, 3104 (2012).
X. Chen, Z. Guo, G.M. Yang, J. Li, M.Q. Li, J.H. Liu, and X.J. Huang, Mater. Today 13, 28 (2010).
P. Bergveld, IEEE Trans. Bio-med. Eng. 5, 342 (1972).
P. Bergveld, Sensors Actuat. B: Chem. 88, 1 (2003).
B. Palan, F.V. Santos, J.M. Karam, B. Courtois, and M. Husak, Sensors Actuat. B: Chem. 57, 63 (1999).
P.W. Cheung, Theory, Design and Biomedical Applications of Solid State Chemical Sensors (Boca Raton: CRC Press, 1978), pp. 165–173.
S. Caras and J. Janata, Anal. Chem. 52, 1935 (1980).
M. Yuqing, G. Jianguo, and C. Jianrong, Biotechnol. Adv. 21, 527 (2003).
H. Im, X.J. Huang, B. Gu, and Y.K. Choi, Nat. Nanotechnol. 2, 430 (2007).
A.K. Okyay, O. Hanoglu, M. Yuksel, H. Acar, S. Sülek, B. Tekcan, and M.O. Guler, Microsyst. Technol. 23, 889 (2017).
C.H. Kim, C. Jung, K.B. Lee, H.G. Park, and Y.K. Choi, Nanotechnology 22, 135502 (2011).
C.H. Kim, C. Jung, H.G. Park, and Y.K. Choi, Biochip J. 2, 127 (2008).
L. Torsi, M. Magliulo, K. Manoli, and G. Palazzo, Chem. Soc. Rev. 42, 8612 (2013).
D. Sarkar, and K. Banerjee, in 70th Device Research Conference IEEE (2012), p. 83.
T. Goda and Y. Miyahara, Biosens. Bioelectron. 45, 89 (2013).
R. Narang, M. Saxena, R.S. Gupta, and M. Gupta, IEEE Electron. Device Lett. 33, 266 (2011).
G. Wadhwa and B. Raj, J. Electron. Mater. 47, 4683 (2018).
M. Donnelly, D. Mao, J. Park, and G. Xu, J. Phys. D Appl. Phys. 51, 493001 (2018).
Y. Kim, T. Lim, C.H. Kim, C.S. Yeo, K. Seo, S.M. Kim, and M.H. Yoon, NPG Asia Mater. 10, 1086 (2018).
E. Macchia, M. Ghittorelli, F. Torricelli, and L. Torsi, in 7th IEEE International Workshop (2017), p. 68.
P. Yu, L. Bai, W. Li, C.G. Elósegui, J. Fei, and L. Mao, Front. Chem 7, 313 (2019).
K. Shoorideh and C.O. Chui, Proc. Natl. Acad. Sci. 111, 5111 (2014).
A. Porwal, and C. Sahu, in IEEE Computer Society Annual Symposium on VLSI (2018), p. 281.
H.K. Hunt and A.M. Armani, Nanoscale 2, 1544 (2010).
I. Sarangadharan, A.K. Pulikkathodi, C.H. Chu, Y.W. Chen, A. Regmi, P.C. Chen, and Y.L. Wang, ECS J Solid State Sci. Technol. 7, Q3032 (2018).
B. Ibarlucea, L. Römhildt, F. Zörgiebel, S. Pregl, M. Vahdatzadeh, W. Weber, and G. Cuniberti, Appl. Sci. 8, 950 (2018).
I. Capek, Carbon Nanotubes-Growth and Applications, ed. M. Naraghi (Rijeka: IntechOpen, 2011), p. 75.
S. Naseh, M.J. Deen, and C.H. Chen, Microelectron. Reliab. 46, 201 (2006).
S.J. Lee, C.H. Choi, A. Kamath, R. Clark, and D.L. Kwong, IEEE Electr. Device Lett. 24, 105 (2003).
A.N. Sokolov, M.E. Roberts, and Z. Bao, Mater. Today 12, 12 (2009).
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Wadhera, T., Kakkar, D., Wadhwa, G. et al. Recent Advances and Progress in Development of the Field Effect Transistor Biosensor: A Review. J. Electron. Mater. 48, 7635–7646 (2019). https://doi.org/10.1007/s11664-019-07705-6
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DOI: https://doi.org/10.1007/s11664-019-07705-6