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Integration of microfluidic injection analysis with carbon nanomaterials/gold nanowire arrays-based biosensors for glucose detection

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  • Materials Science
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Abstract

Carbon nanotubes (CNTs) and reduced graphene oxide (rGO) nanosheets were utilized to construct glucose biosensors in combination with gold nanowire arrays (AuNWAs), and microfluidic injection analysis driven by gravity force was used to investigate the performances of as-prepared glucose biosensors. The results demonstrated glucose biosensors based on carbon nanomaterials/AuNWAs presented excellent performance at low working potential of −0.2 V versus Ag/AgCl (3 mol/L KCl), such as high sensitivity, good anti-interference ability and high throughput (45 h−1). The glucose biosensor based on glucose oxidase (GOx)–CNT–AuNWAs showed a wide linear range from 100 to 3,000 µmol/L with a sensitivity of 4.12 µA/cm2 mmol/L. Furthermore, the linear range and sensitivity of GOx–rGO–AuNWAs-based glucose biosensor were 50–4,000 µmol/L and 8.59 µA/(cm2 mmol/L), respectively, which were better than those of glucose biosensor based on GOx–CNT–AuNWAs, suggesting rGO nanosheets in combination with AuNWAs being a good platform for the construction of glucose biosensors.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (51272063 and 51402081), the Natural Science Foundation of Anhui Province (1408085QB42), the Fundamental Research Funds for the Central Universities (JZ2014HGBZ0010) and the Science and Technology Planning Project of Tongling (2015CXZX02).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Hefei University of Technology, Hefei, 230009, China

    Yongqiang Qin, Jiewu Cui, Yong Zhang, Yan Wang, Hongmei Zheng, Xia Shu, Bowen Fu & Yucheng Wu

  2. Key Laboratory of Advanced Functional Materials and Devices of Anhui Province, Hefei, 230009, China

    Jiewu Cui, Yong Zhang, Yan Wang, Xinyi Zhang, Xia Shu & Yucheng Wu

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  1. Yongqiang Qin
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  2. Jiewu Cui
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  3. Yong Zhang
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  4. Yan Wang
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  5. Xinyi Zhang
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  6. Hongmei Zheng
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  7. Xia Shu
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  8. Bowen Fu
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  9. Yucheng Wu
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Correspondence to Xinyi Zhang or Yucheng Wu.

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Qin, Y., Cui, J., Zhang, Y. et al. Integration of microfluidic injection analysis with carbon nanomaterials/gold nanowire arrays-based biosensors for glucose detection. Sci. Bull. 61, 473–480 (2016). https://doi.org/10.1007/s11434-016-1013-2

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  • DOI: https://doi.org/10.1007/s11434-016-1013-2

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