Abstract
Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.
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Dedicated to Academician of the Russian Academy of Sciences I. P. Beletskaya.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0558—0561, March, 2018.
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Borisova, M.S., Yarovaya, O.I., Semenova, M.D. et al. Antiulcerogenic activity of borneol derivatives. Russ Chem Bull 67, 558–561 (2018). https://doi.org/10.1007/s11172-018-2110-y
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DOI: https://doi.org/10.1007/s11172-018-2110-y