Abstract
Hemorrhage control is crucial in both military and civilian contexts. Despite unprecedented improvements in hemostatic products, efficient treatment solutions to control hemorrhage upon wound healing are still necessary. Chitosan (CS) and dextran (Dex) are natural, biocompatible and biodegradable hydrogel-forming polysaccharides with enhanced hemostatic and wound healing properties. Bioglass nanoparticles (BG-nps) in turn possess documented hemostatic properties. In this context, in the present work, a series of BGnps-doped chitosan (CS)/oxidized-dextran (ODEX) adhesive sponges were developed through a Schiff base reaction. The successful synthesis of the materials was confirmed by FTIR spectroscopy, their crystallinity was analyzed by XRD, the sponge morphology was investigated by SEM analysis, water swelling, and viscosity of the hydrogels were also investigated. All materials were developed in powder and sponge form with the aim to allow their application to wound lesions of any shape and depth and enable suppression of external bleeding for which other methods of bleeding control are not applicable. All prepared hemostatic products showed hemocompatibility, and it was observed that the CS-ODEX-BGnps sponges decreased the blood clotting time compared to CS neat and mainly those with the highest percentages of BGnps (1% and 2% w/w).
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Bikiaris, R.E., Tsamesidis, I., Kontonasaki, E. et al. Chitosan/oxidized-dextran dressings containing mesoporous bioglass nanoparticles for hemostatic applications. J Mater Sci (2024). https://doi.org/10.1007/s10853-024-10241-2
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DOI: https://doi.org/10.1007/s10853-024-10241-2