We studied the effect of long-term light deprivation which began at different stages of ontogeny on the content of α-tocopherol in rats during the first 3 months of postnatal development. In the offspring postnatally exposed to constant darkness, the level of α-tocopherol in the liver, kidneys, heart, skeletal muscles, and lungs was significantly decreased at the early stages of postnatal ontogeny (2 weeks and 1 month). In rats kept under constant darkness after birth, the content of α-tocopherol in the lungs was also reduced at the age of 1 month. The modulating effect of light deprivation on the level of α-tocopherol can be associated both with the impact of disturbed circadian rhythms and with increased content of melatonin in the body.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 9, pp. 281-295, September, 2020
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Baishnikova, I.V., Ilyina, T.N., Khizhkin, E.A. et al. Effect of Long-Term Light Deprivation on α-Tocopherol Content in Rats during Ontogeny. Bull Exp Biol Med 170, 294–298 (2021). https://doi.org/10.1007/s10517-021-05054-1
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DOI: https://doi.org/10.1007/s10517-021-05054-1