The content of serum albumin was evaluated in the vitreous body, retina, and lens of human fetuses of 14, 16, 17, 18 and 24 weeks of gestation. Albumin was detected in these tissues. PCR analysis revealed no albumin mRNA in the retina or in the lens, while in fetal liver (control) mRNA for this protein was expressed. These findings suggest that serum albumin is not synthesized by cells of retina and lens, but is captured by them. The presence of serum albumin in human eye tissues suggests its involvement in the metabolism, maintenance of tissue volume, and antioxidant reactions.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Panova IG, Tatikolov AS, Sukhikh GT. Correlation between the content of albumin and carotenoids in human vitreous body during prenatal development. Bull. Exp. Biol. Med. 2007;144(5):681-683.
Tatikolov AS, Panova IG, Ishchenko AA, Kudinova MA. Spectral and fluorescent study of the interaction of squarylium dyes, derivatives of 3H-indolium, with albumins. Biophysics. 2010;55(1):35-40.
Fanali G, di Masi A, Trezza V, Marino M, Fasano M, Ascenzi P. Human serum albumin: From bench to bedside. Mol. Aspects Med. 2012;33(3):209-290.
Hankins J. The role of albumin in fluid and electrolyte balance. J. Infus. Nurs. 2006;29(5):260-265.
Jauniaux E, Gulbis B, Jurkovic D, Campbell S, Collins WP, Ooms HA. Relationship between protein concentrations in embryological fluids and maternal serum and yolk sac size during human early pregnancy. Hum. Reprod. 1994;9(1):161-166.
Naval J, Calvo M, Laborda J, Dubouch P, Frain M, Sala-Trepat JM, Uriel J. Expression of mRNAs for alpha-fetoprotein (AFP) and albumin and incorporation of AFP and docosahexaenoic acid in baboon fetuses. J. Biochem. 1992;111(5):649-654.
Panova IG, Tatikolov AS, Stroeva OG. Albumins and carotenoids of the human fetal vitreous body and their morphogenetic role during midgestation. J. J. Ophthalmol. 2015;1(2):013.
Peters T Jr. All about Albumin: Biochemistry, Genetics, and Medical Application. San Diego, 1996.
Prajapati KD, Sharma SS, Roy N. Current perspectives on potential role of albumin in neuroprotection. Rev. Neurosci. 2011;22(3):355-363.
Sabah J, McConkey E, Welti R, Albin K, Takemoto LJ. Role of albumin as a fatty acid carrier for biosynthesis of lens lipids. Exp. Eye Res. 2005;80(1):31-36.
Taverna M, Marie AL, Mira JP, Guidet B. Specific antioxidant properties of human serum albumin. Ann. Intensive Care. 2013;3(1):4. doi: 10.1186/2110-5820-3-4.
Yang J, Klassen H, Pries M, Wang W, Nissen MH. Vitreous humor and albumin augment the proliferation of cultured retinal precursor cells. J. Neurosci. Res. 2009;87(2):495-502.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 11, pp. 578-580, November, 2016
Rights and permissions
About this article
Cite this article
Panova, I.G., Tatikolov, A.S., Smirnova, Y.A. et al. Albumin in the Vitreous Body, Retina and Lens of Human Fetal Eye. Bull Exp Biol Med 162, 629–631 (2017). https://doi.org/10.1007/s10517-017-3673-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3673-6