The effect of aggressive behavior shaped under social stress of various durations on the production of proinflammatory cytokines by splenic cells was examined on C57BL/6J mice. Aggressive mice were characterized by enhanced production of IL-2 and IFN-γ (released by T helper type 1 cells) and reduced secretion of TNF-α, whose major producers are monocytes and macrophages. Elevation of IL-2 and IFN-γ in aggressive mice resulted from enhancement of spontaneous and Con A-stimulated production, the most pronounced effect was demonstrated by the with a longer period (20 days) of victories. In contrast, spontaneous production of TNF-α was similar in control and aggressive mice, although LPS-stimulated production of this cytokine decreased after 10- and 20-day stress. The possible mechanisms of the changes in cytokine production are discussed.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 11, pp. 631-634, November, 2015
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Idova, G.V., Markova, E.V., Gevorgyan, M.M. et al. Changes in Production of Cytokines by C57Bl/6J Mouse Spleen during Aggression Provoked by Social Stress. Bull Exp Biol Med 160, 679–682 (2016). https://doi.org/10.1007/s10517-016-3248-y
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DOI: https://doi.org/10.1007/s10517-016-3248-y