The expression of endothelial and inducible NO synthase in the human adrenal glands was studied under a change in the concentration of K+, which plays a regulatory role in aldosterone secretion. K+ ions stimulated the expression of both isoforms of NO synthase in the human adrenal cortex. A stimulatory effect of K+ on NO synthase is probably related to activation of the calmodulin system and potassium-induced translocation of protein kinase C. Lithium produced n inhibitory effect on both isoforms of NO synthase, which suggests that protein kinase C serves a major regulator of expression in the human adrenal glands.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 9, pp. 307-309, September, 2013
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Kovzun, E.I., Lukashenya, O.S., Pushkarev, V.M. et al. Effect of Ions of Potassium and Lithium on NO Synthase Expression in the Human Adrenal Cortex. Bull Exp Biol Med 156, 332–334 (2014). https://doi.org/10.1007/s10517-014-2342-2
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DOI: https://doi.org/10.1007/s10517-014-2342-2