Antimutagenic effects of polypeptides isolated from Triticum kiharae wheat plantule extracts have been studied on human cells exposed to cadmium chloride. The most effective polypeptide Tk-AMP-BP β-purothionin exhibited higher antimutagenic activity than wheat water extract and another peptide isolated from the same wheat species, Tk-AMP-γ2 defensin; it also produced a pronounced antioxidant effect. This polypeptide can be used as a preventive agent for reducing the mutagenic potential of some environmental pollutants and for correction of human diseases associated with the defense system defects.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 3, pp. 349–351, March, 2013
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Zasukhina, G.D., Vasilyeva, I.M., Kadnikov, I.A. et al. Antimutagenic Activity of Wheat Polypeptides in Human Cells Exposed to Cadmium Chloride. Bull Exp Biol Med 155, 370–372 (2013). https://doi.org/10.1007/s10517-013-2156-7
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DOI: https://doi.org/10.1007/s10517-013-2156-7