We compared the effects of blockade of α1A-, α1В-, and α1D-subtypes of α1-adrenoceptors on the cardiac rhythm in newborn rats. Different responses of the heart were observed after blockade of several subtypes of α1-adrenoceptors. Administration of WB 4101, a selective blocker of α1A-adrenoceptors, increased heart rate, while blockade of α1AD-adrenoceptors with BMY 7378 decelerated of heart rhythm. Blockade of α1В-adrenoceptors with chloroethylclonidine produced no significant effects on heart chronotropy.
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T. L. Zefirov, N. I. Ziyatdinova, A. A. Gaynullin, and A. L. Zefirov, Byull. Eksp. Biol. Med., 133, No. 5, 492–495 (2002).
T. L. Zefirov, N. I. Ziyatdinova, L. I. Khisamieva, and A. L.Zefirov, Byull. Eksp. Biol. Med., 151, No. 6, 607–610 (2011).
J. D. Bisognano, H. D. Weinberger, T. J. Bohlmeyer, et al., J. Mol. Cell. Cardiol., 32, No. 5, 817–830 (2000).
D. Chalothorn, D. F. McCune, S. E. Edelmann, et al., J. Pharmacol. Exp. Ther., 305, No. 3, 1045–1053 (2003).
B. C. Jensen, P. M. Swigart, M. E. Laden, et al., J. Am. Coll. Cardiol., 54, No. 13, 1137–1145 (2009).
B. C. Jensen, P. M. Swigart, T. De Marco, et al., Circ. Heart. Fail., 2, No. 6, 654–663 (2009).
M. J. Lohse, S. Engelhardt, and T. Eschenhagen, Circ. Res., 93, No. 10, 896–906 (2003).
T. D. O’Connell, S. Ishizaka, A. Nakamura, et al., J. Clin. Invest., 111, No. 11, 1783–1791 (2003).
M. T. Piascik and D. M. Perez, J. Pharmacol. Exp. Ther., 298, No. 2, 403–410 (2001).
D. G. Rokosh, A. F. Stewart, K. C. Chang, et al., J. Biol. Chem., 271, No. 10, 5839–5843 (1996).
M. Steinfath, Y. Y. Chen, J. Lavicky, et al., Br. J. Pharmacol., 107, No. 1, 185–188 (1992).
F. Triposkiadis, G. Karayannis, G. Giamouzis, et al., J. Am. Coll. Cardiol., 54, No. 19, 1747–1762 (2009).
L. Turnbull, D. T. McCloskey, T. D. O’Connell, et al., Am. J. Physiol. Heart Circ. Physiol., 84, No. 4, H1104-H1109 (2003).
C. D. Wright, Q. Chen, N. L. Baye, et al., Circ. Res., 103, No. 9, 992–1000 (2008).
W. Z. Zhu, S. Q. Wang, K. Chakir, et al., J. Clin. Invest., 111, No. 5, 617–625 (2003).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 8, pp. 144–146, August, 2012
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Ziyatdinova, N.I., Dementieva, R.E., Fashutdinov, L.I. et al. Blockade of Different Subtypes of α1-Adrenoceptors Produces Opposite Effect on Heart Chronotropy in Newborn Rats. Bull Exp Biol Med 154, 184–185 (2012). https://doi.org/10.1007/s10517-012-1906-2
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DOI: https://doi.org/10.1007/s10517-012-1906-2