The effect of recombinant TNF-α on programmed death of donor lymphocytes was studied in vitro. The proapoptotic effect of this cytokine is realized through transcription factors and cell cycle inhibitors. Incubation of lymphocytes with recombinant TNF-α revealed increased levels of NF-kB and p21 and reducted content of nonphosphorylated p53.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 56–59, January, 2010
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Ryazantseva, N.V., Novitskii, V.V., Zhukova, O.B. et al. Role of NF-kB, p53, and p21 in the Regulation of TNF-α Mediated Apoptosis of Lymphocytes. Bull Exp Biol Med 149, 50–53 (2010). https://doi.org/10.1007/s10517-010-0873-8
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DOI: https://doi.org/10.1007/s10517-010-0873-8