Abstract
Background: Lymphatic invasion is a risk factor for lymph node metastases in patients with gastric cancer. No studies have been reported, however, on the correlation between lymphatic invasion and lymph node metastasis in early gastric cancer invading into the submucosa.
Methods: We performed a retrospective analysis of lymphatic invasion in 170 patients with early gastric cancer invading into the submucosa.
Results: Lymphatic invasion was found in 76 patients. Lymphatic invasion correlated significantly with the presence of lymph node metastasis and vascular invasion (P < .05) and with the degree of cancerous submucosal involvement (P < .05). The presence of lymph node metastasis also correlated with the grade of submucosal invasion and lymphatic invasion. The 5-year survival of patients with lymphatic invasion was poorer than that of patients without lymphatic invasion (P < .05). Node-negative patients had similar survival, regardless of the presence of lymphatic invasion. All patients with severe lymphatic invasion had sm3 invasion and lymph node metastases.
Conclusion: Although lymphatic invasion is the first stage of lymph node metastasis, lymphatic invasion in itself does not have clinical importance except for severe invasion in early gastric cancer. It is possible to predict lymph node metastases from the combined evaluation of degree of lymphatic invasion and submucosal involvement of the tumor in patients with early gastric cancer invading into the submucosa.
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REFERENCES
Seto Y, Nagawa H, Muto T. Impact of lymph node metastasis on survival in early gastric cancer. World J Surg 1997;21:186–189.
Maehara Y, Orita H, Okuyama T, Moriguchi S, Tsujitani S, Korenaga D, Sugimachi K. Predictor of lymph node metastasis in early gastric cancer. Br J Surg 1992;79:245–247.
Tanaka A, Watanabe T, Okuno K, Yasutomi M. Perineural invasion as a predictor of recurrence of gastric Cancer. Cancer 1993;73:550–555.
Sawai K, Takahashi T, Fujioka T, Minato H, Taniguchi H, Yamaguchi T. Pylorus-preserving gastrectomy with radical lymph node dissection based on anatomical variations of the infrapyloric artery. Am J Surg 1995;170:285–288.
Sano T, Kobari O, Muto T. Lymph node metastasis from early gastric cancer: endoscopic resection of tumor. Br J Surg 1992;79:241–244.
Tada M, Murakami A, Karita M, Yanai H, Okita K. Endoscopic resection of early gastric cancer. Endoscopy 1993;25:445–450.
Shirouzu K, Isomoto H, Morodome T, Kakegawa T. Carcinomatous lymphatic permeation. Prognostic significance in patients with rectal carcinoma—a long term prospective study. Cancer 1995;75:4–10.
Guadagni S, Peed PI, Johnston BJ. Early gastric cancer: follow-up after gastrectomy in 159 patients. Br J Surg 1993;80:325–328.
Kim JP, Hur YS, Yang HK. Lymph node metastasis as a significant prognostic factor in early gastric cancer: analysis of 1,136 early gastric cancers. Ann Surg Oncol 1995;2:308–313.
Ichikura T, Uefuji K, Tomimatsu S, Okusa Y, Yahara T, Tamakuma S. Surgical strategy for patients with gastric carcinoma with submucosal invasion. Cancer 1995;76:935–940.
Eriguchi M, Miyamoto Y, Fuji Y, Takeda Y, Osada I, Higihara T. Regional lymph node metastasis of early gastric cancer. Eur J Surg 1995;157:197–200.
Japanese Research Society for Gastric Cancer. The general rules for the gastric cancer study in surgery and pathology. Part I. Jpn J Surg 1981;11:140–145.
Ohta H, Noguchi Y, Takagi K, Nishi M, Kajitani T, Kato Y. Early gastric carcinoma with special reference to macroscopic classification. Cancer 1987;60:1099–1106.
Aikou T, Saihara T, Hokita S, Ishigami S, Natsugoe S. Rational lymphadenectomy for gastric cancer. Jpn J Surg Gastroenterol 1994;27:968–973.
Maehara Y, Oshiro T, Baba H, Ohno S, Kohnoe S, Sugimachi K. Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer. Surgery 1995;117:380–385.
Kanai T, Maruyama K, Baba M, Tanaka T, Maruo Y, Nishino N. p53 overexpression and proliferative activity do not correlate with lymph node metastasis in early gastric cancer. Eur Surg Res 1997;29:35–41.
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Ishigami, S., Natsugoe, S., Hokita, S. et al. Carcinomatous Lymphatic Invasion in Early Gastric Cancer Invading Into the Submucosa. Ann Surg Oncol 6, 286–289 (1999). https://doi.org/10.1007/s10434-999-0286-y
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DOI: https://doi.org/10.1007/s10434-999-0286-y