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Pediatric Hepatic Angiosarcoma: Case Report and Review of the Literature

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Pediatric and Developmental Pathology

Abstract

Pediatric hepatic angiosarcoma (PHAS) is a rare tumor, which usually presents as a rapid enlargement of the liver. To date, surgery, chemotherapy, and radiotherapy have not improved the poor prognosis of PHAS with only three survivors reported. The histology of PHAS is distinct from adult angiosarcoma, because PHAS displays hypercellular whorls of sarcomatous cells, or “kaposiform” spindle cells, in addition to the general features of angiosarcoma. We report a case of PHAS that was treated with vascular ablation, chemotherapy, and liver transplantation. Lung metastases occurred 14 months posttransplant.

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ACKNOWLEDGMENTS

We thank Louis P. Dehner, M.D., at the Washington University Medical Center, for his expert opinion on this case, and Henry Giles, M.D., and Michael Doherty, M.D., at the University of Mississippi Medical Center, for providing image pictures. We also thank Chris Woods and Jay Card for their technical assistance.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA

    Haytham H. Dimashkieh

  2. Division of Pathology, MLC 1010, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA

    Jun Q. Mo & Margaret H. Collins

  3. Department of Pathology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA

    Josephine Wyatt-Ashmead

Authors
  1. Haytham H. Dimashkieh
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  2. Jun Q. Mo
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  3. Josephine Wyatt-Ashmead
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  4. Margaret H. Collins
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Correspondence to Margaret H. Collins.

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Dimashkieh, H., Mo, J., Wyatt-Ashmead, J. et al. Pediatric Hepatic Angiosarcoma: Case Report and Review of the Literature. Pediatr Dev Pathol 7, 527–532 (2004). https://doi.org/10.1007/s10024-004-4041-x

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  • DOI: https://doi.org/10.1007/s10024-004-4041-x

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