Abstract.
A simple flow injection chemiluminescence (CL) method was developed for the determination of atenolol using Eu3+ as the probe. It was found that the weak CL generated by the KMnO4-Na2SO3 reaction can be significantly enhanced by the atenolol-Eu3+ complex. The experimental conditions were optimized. The CL intensity was linearly related to atenolol concentration in the range from 8.0 × 10−9 to 1.0 × 10−5 g mL−1. The detection limit (3s b) was 3 × 10−9 g mL−1 and the relative standard deviation for 1.0 × 10−7 g mL−1 atenolol solution was 2.4% (n = 11). The method has high sensitivity, wide linear range, inexpensive instrumentation, and has been applied to the determination of atenolol in spiked human urine and plasma samples with recoveries within the range 95.5–104.0%.
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Correspondence: Jianxiu Du, Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Materials Science, Shaanxi Normal University, Xi’an 710062, P.R. China
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Li, D., Du, J. & Lu, J. Chemiluminescence determination of atenolol in biological fluids by a europium-sensitized permanganate-sulfite system. Microchim Acta 161, 169–173 (2008). https://doi.org/10.1007/s00604-007-0931-8
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DOI: https://doi.org/10.1007/s00604-007-0931-8