Abstract.
Single-wall carbon nano-tubes were used to modify the surface of a glassy carbon electrode (GC) and applied in the determination of folic acid with voltammetry. The experiments demonstrated that the presence of a carbon nano-tube film on the electrode greatly increased the reduction peak current of folic acid. Cyclic voltammetry (CV) and linear sweep voltammetry (LSV) were used in a comparative investigation of the electrochemical reduction of folic acid with the film electrode. Effects of pH on the peak current and the peak potential were studied in the pH range of 4.0–8.0 with Britton-Robinson buffer solution. The reduction peak current was found to be linearly related to folic acid concentration over the range of 1 × 10−8 to 1 × 10−4 mol L−1 with a detection limit of 1 × 10−9 mol L−1 after 5 min accumulation. The film electrode provides an efficient way for eliminating interferences from some inorganic and organic species in the solution. The high sensitivity, selectivity and stability of the film electrode demonstrate its practical application from a simple and rapid determination of folic acid in tablets.
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References
S J Tans M H Devoret H Dai A Thess R E Smalley L J Geerligs C Dekker (1997) Nature 386 474 Occurrence Handle1:CAS:528:DyaK2sXisVSqt70%3D Occurrence Handle10.1038/386474a0
G Y Liu A J Bard F Wudl (1999) Electrochem Solid State Lett 2 577 Occurrence Handle1:CAS:528:DyaK1MXms1Ons7o%3D
W S Huang W B Hu J C Song (2003) Talanta 61 441 Occurrence Handle10.1016/S0039-9140(03)00302-3
Q Zhao Z N Gu Q K Zhuang (2004) Electrochem Commun 6 83 Occurrence Handle1:CAS:528:DC%2BD3sXovFOis74%3D
The United States Pharmacopeia, 25th revision, United States Pharmacopeial Convention, Rockville, M D. 2002, p 2439
Merck index, 12th ed., Merck, New York, 1996, p 715
C C Blanco S A Carretero F A Gutierrez R M Ceba (1994) Anal Lett 27 1339
G Jahanbakhsh A Bahman N Ali E Nadaf A Mordai (2004) Anal Lett 37 2609
G Padmarajaiah V A Ramanathapura Y S Hemmige (2002) Anal Biochem 307 316
V Adrisano M Bartolini C Bertucci V Cavrini B Luppi T Cerchiara (2003) J Pharm Biomed Anal 32 983
E Breithaupt (2001) Food Chem 74 521 Occurrence Handle1:CAS:528:DC%2BD3MXmt1Gmt7o%3D Occurrence Handle10.1016/S0308-8146(01)00219-9
S Ruggeri L T Vahteristo A Aguzzi P Finglas W Carnovale (1999) J Chormatogr A 855 237 Occurrence Handle1:CAS:528:DyaK1MXmsFWrsL0%3D
R Flores J Penalvo G Castaneda A Mansilla E Gomez M J Rodriguez (2005) J Chromatogr B 819 141
J L F C Lima Q Cakir R D Silva (1997) Port Electrochim Acta 15 321 Occurrence Handle1:CAS:528:DyaK1cXhtVyktLc%3D
L Gall A Christine V D Berg M G Constant (1993) Anal Chim Acta 282 459
W Szczepaniak M Ren (1994) Electroanalysis 6 505 Occurrence Handle1:CAS:528:DyaK2cXltFOrtLY%3D
D B Luo (1986) Anal Chim Acta 189 277 Occurrence Handle1:CAS:528:DyaL2sXhs1altL8%3D Occurrence Handle10.1016/S0003-2670(00)83730-7
J M F Alvarez A C Garcia A J M Ordieres P T Blanco (1987) J Electroanal Chem 225 241 Occurrence Handle10.1016/0022-0728(87)80017-7
E Laviron (1974) J Electroanal Chem 52 355 Occurrence Handle1:CAS:528:DyaE2cXktlamur0%3D
A L G Christine M G Constant V D Berg (1993) Anal Chim Acta 282 459
E M Jacobsen M B Wises (1978) Anal Chim Acta 96 345 Occurrence Handle1:CAS:528:DyaE1cXhsVWkt7w%3D Occurrence Handle10.1016/S0003-2670(01)83671-0
J M R Mellado M Blazquez D Dominguez J J Ruiz (1985) J Electroanal Chem 195 263
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Wang, C., Li, C., Ting, L. et al. Application of a Single-Wall Carbon Nano-Tube Film Electrode to the Determination of Trace Amounts of Folic Acid. Microchim Acta 152, 233–238 (2006). https://doi.org/10.1007/s00604-005-0441-5
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DOI: https://doi.org/10.1007/s00604-005-0441-5