Abstract.
In studies of molecular evolution, the assumption that protein evolution is reversible has often been made, but rarely tested. Here we use a large set of orthologous murid protein coding sequences to perform a simple test of reversibility, and find no evidence to reject the assumption of reversibility in protein evolution.
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Received: 10 October 2000 / Accepted: 18 January 2001
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Smith, N., Eyre-Walker, A. A Test of Amino Acid Reversibility. J Mol Evol 52, 467–469 (2001). https://doi.org/10.1007/s002390010176
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DOI: https://doi.org/10.1007/s002390010176