Abstract.
Dimeric hemoglobins in lampreys are thought to be orthologous to gnathostome hemoglobins, comprising a familiar tetrameric assembly, despite their different subunit interface. To elucidate this contradictory problem, a phylogenetic analysis of vertebrate globins was conducted. The inferred maximum-likelihood trees revealed that the cyclostome hemoglobins are closely related to STAPs, recently identified stellate cell activation-associated proteins, and are paralogous to gnathostome hemoglobins. The quaternary structural difference between cyclostome and gnathostome hemoglobins is well understandable in light of their paralogous relationship.
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Katoh, K., Miyata, T. Cyclostome Hemoglobins Are Possibly Paralogous to Gnathostome Hemoglobins . J Mol Evol 55, 246–249 (2002). https://doi.org/10.1007/s00239-002-2319-z
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DOI: https://doi.org/10.1007/s00239-002-2319-z