Abstract.
Regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with decreased incidence of cancer of the colon and other gastrointestinal organs. The chemopreventive properties of NSAIDs are due to their ability to induce apoptosis. Both COX-2-dependent and COX-2-independent mechanisms are involved in NSAIDs-induced neoplastic growth. This article reviews the recent literature that has revealed various important mechanisms of NSAIDs-induced apoptosis.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Author information
Authors and Affiliations
Corresponding author
Additional information
Received 5 November 2007; received after revision 22 January 2008; accepted 25 January 2008
Rights and permissions
About this article
Cite this article
Jana, N.R. NSAIDs and apoptosis. Cell. Mol. Life Sci. 65, 1295–1301 (2008). https://doi.org/10.1007/s00018-008-7511-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00018-008-7511-x