Abstract
Baker's yeast is one of the micro-organisms that is studied most in literature. Therefore, a lot of knowledge on the biochemical pathways and corresponding yield coefficients is available. This knowledge is combined with measurements of oxygen and carbon dioxide in the exit-gas to determine the coefficients appearing in the stoichiometric equations. In this manner, two measurements are sufficient to yield on-line estimates for biomass, glucose, ethanol and the specific growth rate, and information about the (ill-defined) nitrogen source NH q . This is not possible if the yield coefficients are not included in the estimation procedure. A sensitivity analysis illustrates that this estimation scheme is rather insensitive to uncertainties on the yield coefficients.
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Received: 18 February 1999
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Claes, J., Van Impe, J. Combining yield coefficients and exit-gas analysis for monitoring of the baker's yeast fed-batch fermentation. Bioprocess Engineering 22, 195–200 (2000). https://doi.org/10.1007/PL00009111
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DOI: https://doi.org/10.1007/PL00009111