Abstract
A 26-week-old female cerebellar vermis defect (CVD) rat, a mutant with cerebellar vermis defect and cerebellar dysplasia, developed a brain tumor about 10 mm in diameter. Histopathologically, the tumor consisted of diffuse proliferation of small round to ovoid cells with hyperchromatic nuclei, occasionally containing round to strap-shaped myoblastic cells. Immunohistochemically, the small round cells expressed neuron-specific enolase and synaptophysin, indicating neuronal differentiation; myoblastic components reacted to desmin, myoglobin, and vimentin. Based on these findings, the case was diagnosed as a medullomyoblastoma (MMB). Furthermore, two cerebella tumors in CVD rats, which were induced by transplacental application of ethyl-nitrosourea, showed histopathology similar to the aforementioned case. MMB is a very rare tumor in humans and animals; thus, it is noteworthy that MMBs developed in CVD rats, involving the dysplastic cerebellum with abnormal migration of external granule cells.
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Received: 10 May 1999 / Revised, accepted: 29 June 1999
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Kuwamura, M., Shirota, A., Takada, A. et al. Spontaneous and ethyl-nitrosourea-induced medullomyoblastomas in cerebellar vermis defect (CVD) mutant rats. Acta Neuropathol 99, 285–288 (2000). https://doi.org/10.1007/PL00007439
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DOI: https://doi.org/10.1007/PL00007439