Abstract.
Molecular parasites that utilize the replication machinery of cells or of in vitro amplification reactions have previously been characterized. By and large, these parasites have been smaller than the viruses or amplicons that gave rise to them. This is likely because shorter genomes can be replicated more quickly. In contrast, we have identified and characterized parasites of an isothermal amplification reaction that are longer than their parental molecules yet replicate much more efficiently. These results raise interesting questions regarding whether the optimal size of replicators reflects a trade-off between the information encoded in a parasite and the information encoded in the machinery replicating that parasite.
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Received: 9 February 1999 / Accepted: 7 June 1999
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Marshall, K., Ellington, A. Molecular Parasites That Evolve Longer Genomes. J Mol Evol 49, 656–663 (1999). https://doi.org/10.1007/PL00006586
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DOI: https://doi.org/10.1007/PL00006586