References
(1998) Monitoring the AIDS pandemic (MAP). The status and trends of the HIV/AIDS epidemics in the world. Geneva MAP, pp. 1–27.
Nicoll A, Gill ON. (1999) The global impact of HIV infection and disease. Commun. Dis. Public Health 2: 85–89.
Joint United Nations Programme on AIDS (UNAIDS) and the World Health Organization (WHO). Report on the global HIV/AIDS epidemic June 1998. UNAIDS & WHO, Geneva, pp. 1–58.
Stoneburner R, Low-Beer D, Tembo G, Mertens T, Asiimus-Okiror G. (1996) Human immunodeficiency virus dynamics in East Africa deduced from surveillance data. Am. J. Epidemiol. 144: 682–695.
Tarantola D, Schwartlander B. (1997) HIV/AIDS epidemics in sub-Saharan Africa: dynamism, diversity and discrete declines? AIDS 11 (suppl B): S5–S21.
Fylkesnes K, Musonda RM, Kasumba K, et al. (1997) The HIV epidemic in Zambia: socio-demographic prevalence patterns and indications of trends among childbearing women: AIDS 11: 339–45.
Hu DJ, Dondero TJ, Rayfield MA, et al. (1996) The emerging genetic diversity of HIV. The importance of global surveillance for diagnostics, research, and prevention. JAMA 275: 210–216.
Hu DJ, Buvé A, Baggs J, van der Groen G, Dondero TJ. (1999) What role does HIV-1 subtype play in trasmission and pathogenesis? An epidemiological perspective. AIDS 13: 873–881.
Dolin R, Masur H, Saag MS (eds.) (1999) AIDS Therapy. Churchill Livingstone, Philadelphia.
CDSC/PHLS: Changes in the incidence of AIDS and in AIDS deaths: the effects of anti-retroviral treatment. CDR Wkly 1997 7: 381.
Mouton Y, Alfandari S, Valette M, et al. (1997) Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centres. AIDS 1: F101–F105.
Centers for Disease Control and Prevention. (1997) Update: trends in AIDS incidence, deaths, and prevalence-United States, 1996. MMWR 46: 165–173.
Hogg RS, O’Shaughnessy MV, Gataric N, et al. (1997) Decline in deaths from AIDS due to new antiretrovirals (letter). Lancet 349: 1294.
Pezzotti P, Napoli PA, Acciai S, et al. (1999) Increasing survival time after AIDS in Italy: the role of new combination antiretroviral therapies. AIDS 13: 249–255.
Delta Coordinating Committee. (1996) Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet 348: 283–291.
Cameron DW, Heath-Chiozzi M, Kravcik S, Mills R, Potthoff A, Henry D. (1996) Prolongation of life and prevention of AIDS complications in advanced HIV immunodeficiency with ritonavir: update. XI International Conference on AIDS. Vancouver, July 1996 vol 1: 24 [abstract MoB411].
Hammer SM, Squires KE, Hughes MD, et al. (1997) A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. N. Engl. J. Med. 337: 725–733.
Brodt HR, Kamps BS, Gute P, Knupp B, Staszewski S, Helm EB. (1997) Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapy. AIDS 11: 1731–1738.
Hirschel B, Francioli P. (1998) Progress and problems in the fight against AIDS. N. Engl. J. Med. 338: 906–908.
Connor EM, Sperling RS, Gelber R, et al. (1994) Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N. Engl. J. Med. 331: 1173–1180.
Seage GR, Mayer KH, Horsburgh CR. (1993) Risk of human immunodeficiency virus infection from unprotected receptive anal intercourse increases with decline in immunologic status of infected partners. Am. J. Epidemiol. 137: 899–908.
Lee TH, Sakahara N, Fiebig E, Busch MP, O Brien TR, Herman SA. (1996) Correlation of HIV-1 RNA levels in plasma and heterosexual transmission of HIV-1 from infected transfusion recipients. J. Acquir. Immune Defic. Syndr. Hum. Retrov. 12: 427–428.
Ragni MV, Faruki H, Kingsley LA. (1998) Heterosexual HIV-1 transmission and viral load in hemophilic patients. J. Acquir. Immune Defic. Syndr. Hum. Retrov. 17: 42–45.
Vernazza PL, Eron JJ, Fiscus SA, Cohen MS. (1999) Sexual transmission of HIV: infectiousness and prevention. AIDS 13: 155–166.
Zhu T, Zang N, Carr A, et al. (1996) Generic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission. J. Virol. 70: 3098–4107.
Coombs RW, Speck CE, Hughes JP, et al. (1998) Association between culturable human immunodeficiency virus type 1(HIV-1) in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood. J. Infect. Dis. 177: 320–330.
Cohen MS, Hoffman IF, Royce RA, et al. (1997) Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. Lancet 349: 1868–1873.
Mostad SB, Overbaugh J, DeVange DM, et al. (1997) Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina. Lancet 350: 922–927.
Zhang H, Dornadula G, Beumont M, et al. (1998) Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy. N. Engl. J. Med. 339: 1803–1809.
Mayaux MJ, Teglas JP, Mandelbrot L, Berebi A, Gallais H, Matherton S. (1997) Acceptability and impact of zidovudine prevention on mother-to-child HIV 1 transmission in France. J. Paediatr. 131: 857–862.
Fiscus SA, Adimora AA, Schoenbach VJ, et al. (1996) Perinatal HIV infection and the effect of zidovudine therapy on transmission in rural and urban counties. JAMA 275: 1483–1488.
Stringer JSA, Rouse DJ, Goldenberg RL. (1999) Prophylactic cesarean delivery for the prevention of perinatal human immunodeficiency virus transmission: the case for restraint. JAMA 281: 1946–1949.
The International Perinatal HIV Group. (1999) The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1: a meta-analysis of 15 prospective cohort studies. N. Engl. J. Med. 340: 977–987.
The European Mode of Delivery Collaboration. (1999) Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial. Lancet 353: 1035–1039.
Shaffer N, Chuachoowong R, Mock PA, et al. (1999) Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial. Lancet 353: 773–780.
Wiktor SZ, Ekpini E, Karon JM, et al. (1999) Short course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Côte d’Ivoire: a randomised trial. Lancet 353: 781–785.
Dabis F, Msellati P, Meda N, et al. (1999) 6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovidine to reduce vertical transmission of HIV in breasted children in Côte d’Ivoire and Burkina Faso: a double-blind placebo-controlled multicentre trial. Lancet 353: 786–792.
Mansergh G, Haddix AC, Steketee RW, et al. (1996) Cost-effectiveness of short-course zidovudine to prevent perinatal HIV type 1 infection in a sub-Saharan Africa developing country setting. JAMA 276: 139–145.
Söderlund N, Zwi K, Kinghorn A, Gray G. (1999) Prevention of vertical transmission of HIV: analysis of cost effectiveness of options available in South Africa. BMJ 318: 1650–1656.
(1998) AIDS, the unbridgable gap. Lancet 351: 1825.
Guay LA, Musoke P, Fleming T, et al. (1999) Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomized trial. Lancet 354: 795–802.
Forsythe S, Gilks C. (1999) Economic issues and antiretroviral therapy in developing countries. Trans. R. Soc. Trop. Med. Hyg. 93: 1–3.
Langlois AJ, Desrosiers RC, Lewis MG, et al. (1998) Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus. J. Virol. 72: 6950–6955.
Gauduin MC, Parren PW, Weir R, Barbas CF, Burton DR, Koup RA. (1997) Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1. Nat. Med. 3: 1389–1393.
Prince AM, Reesink H, Pascual D, et al. (1991) Prevention of HIV infection by passive immunization with HIV immunoglobulin. AIDS Res. Hum. Retro. 7: 971–973.
Emini EA, Schleif WA, Nunberg JH, et al. (1992) Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody. Nature 355: 728–730.
Mascola JR, Snyder SW, Weislow OS, et al. (1996) Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. J. Infect. Dis. 173: 340–348.
Belshe RB, Graham BS, Keefer MC, et al. (1994) Neutralizing antibodies to HIV-1 in seronegative volunteers immunized with recombinant gp120 from the MN strain of HIV-1. JAMA 272: 475–480.
Belshe RB, Gorse GJ, Mulligan MJ, et al. (1998) Induction of immune responses to HIV-1 by canarypox virus (ALVAC) HIV-1 and gp120 SF-2 recombinant vaccines in uninfected volunteers. AIDS 12: 2407–2415.
Belshe RB, Bolognesi DP, Clements ML, et al. (1994) HIV infection in vaccinated volunteers. JAMA 272: 431.
Kahn JO, Steimer KS, Baenziger J, et al. (1995) Clinical, immunologic, and virologic observations related to human immunodeficiency virus (HIV) type 1 infection in a volunteer in an HIV-1 vaccine clinical trial. J. Infect. Dis. 171: 1343–1347.
Reitter JN, Means RE, Desrosiers RC. (1998) A role for carbohydrates in immune evasion in AIDS. Nat. Med. 4: 679–684.
Devico A, Silver A, Thronton AM, Sarngadharan MG, Pal R. (1996) Covalently crosslinked complexes of human immunodeficiency virus type 1 (HIV-1) gp120 and CD4 receptor elicit a neutralizing immune response that includes antibodies selective for primary virus isolates. Virology 218: 258–263.
LaCasse RA, Follis KE, Trahey M, Scarborough JD, Littman DR, Nunberg JH. (1999) Fusioncompetent vaccines: broad neutralization of primary isolates of HIV. Science 283: 357–362.
Koup R. A., Safrit J. T., Cao Y., et al. (1994) Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68: 4650–4655.
Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MBA. (1994) Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68: 6103–6110.
Yasutomi Y, Reimann KA, Lord CI, Miller MD, Letvin NL. (1993) Simian immunodeficiency virus-specific CD8+ T lymphocyte response in acutely infected rhesus monkeys. J. Virol. 67: 1707–1711.
Kuroda MJ, Schmitz JE, Charini WA, et al. (1999) Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys. J. Immunol. 162: 5127–5133.
Schmitz JE, Kuroda MJ, Santra S, et al. (1999) Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283: 857–860.
Price DA, Goulder PJ, Klenerman P, et al. (1997) Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. U.S.A. 94: 1890–1895.
Goulder PJ, Phillips RE, Colbert RA, et al. (1997) Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3: 212–217.
Borrow P, Lewicki H, Wei X, et al. (1997) Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3: 205–211.
Wilson CC, Brown RC, Korber BT, et al. (1999) Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant. J. Virol. 73: 3975–3985.
Wagner R, Leschonsky B, Harrer E, et al. (1999) Molecular and functional analysis of a conserved CTL epitope in HIV-1 p24 recognized from a long-term nonprogressor: constraints on immune escape associated with targeting a sequence essential for viral replication. J. Immunol. 162: 3727–3734.
Ferrari G, Humphrey W, McElrath MJ, et al. (1997) Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers. Proc. Natl. Acad. Sci. U.S.A. 94: 1396–1401.
Cao H, Kanki P, Sankale JL, et al. (1997) Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development. J. Virol. 71: 8615–8623.
Rosenberg ES, Billingsley JM, Caliendo AM, et al. (1997) Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 278: 1447–1450.
Schrum S, Probst P, Fleischer B, Zipfel PF. (1996) Synthesis of the CC-chemokines MIP-1α, MIP-1β, and RANTES is associated with a type 1 immune response. J. Immunol. 157: 3598–3604.
Miskovsky E. P., Liu A. Y., Pavlat W., et al. (1994) Studies of the mechanism of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines. J. Immunol. 153: 2787–2799.
Paul WE, Seder RA. (1994) Lymphocyte responses and cytokines. Cell 76: 241–251.
Rissoan MC., Soumelis V., Kadowaki N., et al. (1999) Reciprocal control of T helper cell and dendritic cell differentiation. Science 283: 1183–1186.
Doherty TM, Coffman RL. (1996) Leishmania major: effect of infectious dose on T cell subset development in BALB/c mice. Exp. Parasitol. 84: 124–135.
Sieling PA, Wang XH, Gately MK, et al. (1994) IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J. Immunol. 153: 3639–3647.
Cohen J. (1993) T cell shift: key to AIDS therapy? Science 262: 175–176.
Mestecky J, McGhee JR. (1987) Immunoglobulin IgA: molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv. Immunol. 40: 153–245.
Kraehenbuhl, JP, Neutra MR. (1992) Molecular and cellular basis of immune protection of mucosal surfaces. Physiological Rev. 72: 853–879.
Kawabata S, Miller CJ, Lehner T, et al. (1998) Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques. J. Infect. Dis. 177: 26–33.
McGhee JR, Kiyono H, Kubota M, et al. (1999) Mucosal Th1-versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques. J. Infect. Dis. 179 (Suppl 3): S480–S484.
Petitprez K, Khalife J, Cetre C, et al. (1999) Cytokine mRNA expression in lymphoid organs associated with the expression of IgA response in the rat. Scand. J. Immunol. 49: 14–20.
Yamamoto S, Kiyono H, Yamamoto M, et al. (1997) A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc. Natl. Acad. Sci. U.S.A. 94: 5267–5272.
Whitmire JK, Asano MS, Murali-Krishna K, Suresh M, Ahmed R. (1998) Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection. J. Virol. 72: 8281–8288.
Poccia F, Battistini L, Cipriani B, et al. (1999) Phosphoantigen-reactive Vγ9Vδ2 T lymphocytes suppress in vitro human immunodeficiency virus type 1 replication by cell-released antiviral factors including CC chemokines. J. Infect. Dis. 180: 858–861.
Wallace M, Bartz SR, Chang W-L, MacKenzie D, Pauza CD, Malkovsky M. (1996) γδ T lymphocytes responses to human immunodeficiency virus. Clin. Exp. Immunol. 103: 177–184.
Poccia F, Malkovsky M, Pollak A, et al. (1999) In vivo γδ T-cell priming to mycobacterial antigens by primary M. tuberculosis infection and exposure to nonpeptidic ligands. Mol. Med. 5: 471–476.
Jacob J, Baltimore D. (1999) Modeling T-cell memory by genetic marking of memory T cells in vivo. Nature 399: 593–597.
Sourdive DJ, Murali-Krishna K, Altman JD, et al. (1998) Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J. Exp. Med. 188: 71–82.
Castan J, Tenner R, Racz P, Fleischer B, Broker BM. (1997) Accumulation of CTLA-4-expressing T lymphocytes in the germinal centres of human lymphoid tissues. Immunology 90: 265–271.
Re MC, Furlini G, Vignoli M, et al. (1995) Effect of antibody to HIV-1 Tat protein on viral replication in vitro and progression of HIV-1 disease in vivo. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 10: 408–416.
Zagury JF, Sill A, Blattner W, et al. (1998) Antibodies to the HIV-1 Tat protein correlated with nonprogression to AIDS: a rationale for the use of Tat toxoid as an HIV-1 vaccine. J. Hum. Virol. 1: 282–292.
Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. (1998) Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393: 648–659.
D’Souza MP, Harden VA. (1996) Chemokines and HIV-1 second receptors. Confluence of two fields generates optimism in AIDS research. Nat. Med. 2: 1293–1300.
Lynch JA, deSouza M, Robb MD, et al. (1998) Cross-clade cytotoxic T cell response to human immunodeficiency virus type 1 proteins among HLA disparate North Americans and Thais. J. Infect. Dis. 178: 1040–1046.
Bernard NF, Pederson K, Chung F, Ouellet L, Wainberg MA, Tsoukas CM. (1998) HIV-specific cytotoxic T-lymphocyte activity in immunologically normal HIV-infected persons. AIDS 12: 2125–2139.
Chenciner N, Michel F, Dadaglio G, et al. (1989) Multiple subsets of HIV-specific cytotoxic T lymphocytes in humans and in mice. Eur. J. Immunol. 19: 1537–1544.
Larsson M., Jin X., Ramratnam B., et al. (1999) A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals. AIDS 13: 767–777.
Collins KL, Chen BK, Kalams SA, Walker BD, Baltimore D. (1998) HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391: 397–401.
Sette A, Sidney J. (1998) HLA supertypes and supermotifs: a functional perspective on HLA polymorphism. Curr. Opin. Immunol. 10: 478–482.
Thomson SA, Sherritt MA, Medveczky J, et al. (1998) Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination. J. Immunol. 160: 1717–1723.
Woodberry T, Gardner J, Mateo L, et al. (1999) Immunogenicity of a human immunodeficiency virus (HIV) polytope vaccine containing multiple HLA A2 HIV CD8(+) cytotoxic T-cell epitopes. J. Virol. 73: 5320–5325.
Stott EJ, Chan WL, Mills KH, et al. (1990) Preliminary report: protection of cynomolgus macaques against simian immunodeficiency virus by fixed infected-cell vaccine. Lancet 336: 1538–1541.
Cranage MP, Polyanskaya N, McBride B, et al. (1993) Studies on the specificity of the vaccine effect elicited by inactivated simian immunodeficiency virus. AIDS Res. Hum. Retroviruses 9: 13–22.
Arthur LO, Bess JW Jr, Urban RG, et al. (1995) Macaques immunized with HLA-DR are protected from challenge with simian immunodeficiency virus. J. Virol. 69: 3117–3124.
Polyanskaya N, Sharpe S, Cook N, et al. (1997) Anti-major histocompatibility complex antibody responses to simian B cells do not protect macaques against SIVmac infection. AIDS Res. Hum. Retroviruses 13: 923–931.
Cairns JS, Sarver N. (1998) New viral vectors for HIV vaccine delivery. AIDS Res. Hum. Retroviruses 14: 1501–1508.
Stott EJ, Schild GC. (1996) Strategies for AIDS vaccines. J. Antimicrob. Chemother. 37 (Suppl B): 185–98.
Vogel FR. (1998) Adjuvants in perspective. Dev. Biol. Stand. 92: 241–248.
Alving CR, Detrick B, Richards RL, Lewis MG, Shafferman A, Eddy GA. (1993) Novel adjuvant strategies for experimental malaria and AIDS vaccines. Ann. N.Y. Acad. Sci. 690: 265–275.
Hoff R, Barker LF. (1995) Trial objectives and end points for measuring the efficacy of HIV vaccines. Infect. Agents Dis. 4: 95–101.
Acknowledgments
We thank Drs. Carl Dieffenbach, Nava Sarver, and Paolo Miotti for helpful comments on the manuscript. This work was supported by Min-istero della Sanità, Ricerca corrente IRCCS Spallanzani and the NIH.
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Ippolito, G., Rezza, G., Girardi, E. et al. HIV Infections: The Global Epidemiology and Goals for Vaccine Research. Mol Med 6, 69–85 (2000). https://doi.org/10.1007/BF03401775
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DOI: https://doi.org/10.1007/BF03401775