References
Bongarzone I., Pierotti M.A., Monzini N., Mondellini P., Manenti G., Donghi R., Pilotti S., Grieco M., Santoro M., Fusco A., Vecchio G., Delia Porta G. High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma. Oncogene 4: 1457, 1989.
Klein R., Jing S., Nanduri V., O’Rourke E., Barbacid M. The trk proto-oncogene encodes a receptor for nerve growht factor. Cell 65: 189, 1991.
Hempstead B.L., Martin-Zanca D., Kaplan D.R., Parada L.F., Chao M.V. High-affinity NGF binding requires coexpression of the trk protooncogene and the low-affinity NGF receptor. Nature 350: 678, 1991.
Martin-Zanca D., Barbacid M., Parada L.F. Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes & Development 4: 683, 1990.
Martin-Zanca D., Hughes S.H., Barbacid M. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature 319: 743, 1986.
Kozma S.C., Redmond S.M.S., Xiao-Chang F., Saurer S.M., Groner B., Hynes N.E. Activation of the receptor kinase domain of the TRK oncogene by recombination with two different cellular sequences. EMBO J. 7: 147, 1988.
Miozzo M., Pierotti M.A., Sozzi G., Radice P., Bongarzone I. Spurr N.K., Delia Porta G. Human TRK proto-oncogene maps to chromosome 1q32-q41. Oncogene, 5: 1411, 1990.
Radice P., Sozzi G., Miozzo M., De Benedetti V., Cariani T., Bongarzone I., Spurr N.K., Pierotti M.A., Delia Porta G. The human tropomyosin gene involved in the generation of the trk oncogene maps to chromosome 1q31. Oncogene 6: 2145, 1991.
Sozzi G., Bongarzone I., Miozzo M., Cariani C.T., Mondellini P., Calderone C, Pilotti S., Pierotti M.A., Delia Porta G. Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas. Genes Chrom. Cancer 5: 212, 1992.
Greco A., Pierotti M.A., Bongarzone I., Pagliardini S., Lanzi C., Delia Porta G. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene 7: 237, 1992.
Park M., Dean M., Cooper C.S., Schmidt M., O’Brien S.J., Blair D.G., Vande Woude G.F. Mechanism of met oncogene activation. Cell 45: 895, 1986.
Park M., Dean M., Kaul K., Braun M.J., Gonda M.A., Vande Woude G.F. Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc. Natl. Acad. Sci. USA 84: 6379, 1987.
Bottaro D.P., Rubin S.J., Faletto D.L., Chan A.M.-L, Kmiecik T.E., Vande Woude G.F., Aaronson S.A. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251: 802, 1991.
Naldini L., Vigna E., Narsimhan R.P., Gaudino G. Zarnegar R., Michalopoulos G.K., Comoglio P.M. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the photo-oncogene C-MET. Oncogene 6: 501, 1991.
Mitchell P.J., Cooper C.S. The human tpr gene encodes a protein of 2094 amino acids that has extensive coiled-coil regions and an acidic C-terminal domain. Oncogene 7: 2329, 1992.
Greco A., Mariani C, Miranda C. Pagliardini S., Pierotti M.A. Characterization of the NTRK1 genomic region involved in chromosomal rearrangements generating TRK oncogenes. Genomics 18: 397, 1993.
Greco A., Orlandi R. Mariani C., Miranda C., Borrello M.G., Cattaneo A., Pagliardini S., Pierotti M.A. Expression of TRK-T1 oncogene induces differentiation of PC12 cells. Cell Growth & Differentiation 4: 539, 1993.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pierotti, M.A., Bongarzone, I., Borrello, M.G. et al. Rearrangements of TRK proto-oncogene in papillary thyroid carcinomas. J Endocrinol Invest 18, 130–133 (1995). https://doi.org/10.1007/BF03349721
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03349721