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Eating disorders and diabetic ketoacidosis in a pregnant woman with type 1 diabetes: A case report

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Abstract

OBJECTIVE: To describe a case of diabetic ketoacidosis (DKA) in a pregnant woman with type 1 diabetes (T1DM) and disordered eating behaviour treated with a continuous subcutaneous insulin infusion, and to discuss some aspects of the monitoring and management of DKA in pregnancy and whether a pump is the safest therapeutic choice in the presence of some eating disorders. CASE REPORT: This 26-year-old Caucasian woman affected by T1DM was hospitalised during the last weeks of her fourth pregnancy because of DKA due to disordered eating. She was treated with a fluid infusion, intravenous insulin, and her electrolyte imbalance was carefully corrected. An elective cesarean section was performed after the correction of DKA in the 34th week (+6 days) of gestation. CONCLUSIONS: We suggest that pregnancy in T1DM women with eating disorders may not be rare. The prevention, early recognition and aggressive management of DKA can minimise the possible complications, and is mandatory for the safety of the fetus and mother.

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References

  1. Pinelli L, Rabbone I, Salardi S, et al. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetology. Insulin pump therapy in children and adolescents with type 1 diabetes: the Italian viewpoint. Acta Biomed 2008; 79: 57–64.

    PubMed  Google Scholar 

  2. ISPAD Clinical Practice Consensus Guidelines 2006–2007. Pediatr Diabetes 2007; 8: 28–43.

    Google Scholar 

  3. Goebel-Fabbri AE. Disturbed eating behaviors and eating disorders in type 1 diabetes: clinical significance and treatment recommendations. Curr Diab Rep 2009; 9: 133–9.

    Article  PubMed  Google Scholar 

  4. Iafusco D, Vanelli M, Gugliotta M, et al. Prevalence of eating disorders in young patients with type 1 diabetes from two different Italian cities. Diabetes Care 2004; 27: 2278.

    Article  PubMed  Google Scholar 

  5. Pinhas-Hamiel O, Graph-Barel C, Boyko V, et al. Longterm insulin pump treatment in girls with type 1 diabetes and eating disorders. Is it feasible? Diabetes Technol Ther 2010; 30: 148–52.

    Google Scholar 

  6. Burbos N, Shiner AM, Morris E. Severe metabolic acidosis as a consequence of acute starvation in pregnancy. Arch Gynecol Obstet 2009; 279: 399–400.

    Article  PubMed  Google Scholar 

  7. Guo RX, Yang LZ, Li LX, et al. Diabetic ketoacidosis in pregnancy tends to occur at lower blood glucose levels: case-control study and a case report of euglycemic diabetic ketoacidosis in pregnancy. J Obstet Gynaecol Res 2008; 34: 324–30.

    Article  CAS  PubMed  Google Scholar 

  8. Parker JA, Conway DL. Diabetic ketoacidosis in pregnancy. Obstet Gynecol Clin North Am 2007; 34: 533–43.

    Article  PubMed  Google Scholar 

  9. Sheikh-Ali M, Karon BS, Basu A, et al. Can serum β — hydroxybutyrate be used to diagnose diabetic ketoacidosis? Diabetes Care 2008; 31: 643–7.

    Article  CAS  PubMed  Google Scholar 

  10. Prisco F, Picardi A, Iafusco D, et al. Blood ketone bodies in patients with recent-onset type 1 diabetes (a multicenter study). Pediatr Diabetes 2006; 7: 223–8.

    Article  PubMed  Google Scholar 

  11. Kitzmiller JL, Block JM, Brown FM, et al. Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care. Diabetes Care 2008; 31: 1060–79.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Turan S, Omar A, Bereket A. Comparison of capillary blood ketone measurement by electrochemical method and urinary ketone in treatment of diabetic ketosis and ketoacidosis in children. Acta Diabetologica 2008; 45: 83–5.

    Article  CAS  PubMed  Google Scholar 

  13. Yamamoto N, Yasuyuki F, Sahoji S. Fulminant type 1 diabetes during pregnancy: a case report and review of the literature. J Obstet Gynaecol Med Res 2007; 4: 552–6.

    Article  Google Scholar 

  14. Fadda GM, Cherchi PL, D’Antona D, et al. Umbelical artery pulsatility index in pregnancies complicated by insulin-dependent diabetes mellitus without hypertension. Gynecol Obstet Invest 2001; 51: 173–7.

    Article  CAS  PubMed  Google Scholar 

  15. Siddiqui F, James D. Fetal monitoring in type I diabetic pregnancies. Hearly Human Development 2003; 72: 1–13.

    Article  Google Scholar 

  16. Yuen N, Anderson SE, Glaser N. Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis. Diabetes 2008; 57: 2588–94.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Schneider MB, Umpierrez G, Ramsey R, et al. Pregnancy complicated by diabetic ketoacidosis. Diabetes Care 2003; 26: 958–9.

    Article  PubMed  Google Scholar 

  18. Takahashi H. Transient fetal blood flow redistribution induced by maternal diabetic ketoacidosis. Prenat Diagn 2000; 20: 517–25.

    Article  Google Scholar 

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Correspondence to A. Napoli MD.

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Napoli, A., Framarino, M., Colatrella, A. et al. Eating disorders and diabetic ketoacidosis in a pregnant woman with type 1 diabetes: A case report. Eat Weight Disord 16, e146–e149 (2011). https://doi.org/10.1007/BF03325322

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  • DOI: https://doi.org/10.1007/BF03325322

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