Abstract
A one-pot four-component reaction of aldehydes, ethyl acetoacetate/5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate in the presence of 10 mol% of ZnO as a heterogeneous catalyst for the synthesis of corresponding 1,4- dihydropyridine and polyhydroquinoline derivatives via the Hantzsch condensation is described. The present methodology offers several advantages such as simple procedure, excellent yields, and short reaction time.
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Moghaddam, F.M., Saeidian, H., Mirjafary, Z. et al. Rapid and efficient one-pot synthesis of 1,4-dihydropyridine and polyhydroquinoline derivatives through the Hantzsch four component condensation by zinc oxide. JICS 6, 317–324 (2009). https://doi.org/10.1007/BF03245840
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DOI: https://doi.org/10.1007/BF03245840