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Medicinal gold compounds

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Abstract

A major use of gold compounds in the pharmaceutical industry is for antiarthritic agents. The disease itself is not understood and little is known about the way in which the drugs act, but detailed pictures of the distribution of gold in the body are available, and some of the relevant biochemistry is beginning to emerge.

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References

  1. G.J. Higby,Gold Bull., 1982,14, 130

    Google Scholar 

  2. K. Landé,Munch. Med. Wochenschr., 1927,74, 1123; J. Forestier,Bull. Mem. Soc. Med. Hop. Paris, 1929,323; T.N. Fraser,Ann. Rheum. Dis., 1945,4, 71; Empire Rheumatism Council,ibid, 1961,20, 315; Amer. Rheum. Ass.,Arth. Rheum., 1973,16, 353

    Google Scholar 

  3. B.M. Sutton,Gold Bull., 1986,19, 15.

    CAS  Google Scholar 

  4. C.K. Mirabelliet al., 20th Great Lakes Regional Amer. Chem. Soc. Mtg., Milwaukee, 1986, Abstr. 204, 243, 244;Eur. Pat. Appl, 1985, 05303851.1 (Smith Kline Beckman Corp.)

    Google Scholar 

  5. R.H. Freyberg, M. Ziff and J. Baum,in ‘Arthritis and Allied Conditions’ J.L. Hollander and D.J. McCarty (eds.), Lea and Febiger, Philadelphia, 8th Ed., 1972, p. 455

    Google Scholar 

  6. N. Zvaifler,in ‘Arthritis and Allied Conditions’ D.J. McCarty (ed.), Lea and Febinger, Philadelphia, 9th Ed., 1979, p. 364

    Google Scholar 

  7. C.F. Shaw,Inorg. Perspect Biol. Med., 1979,2, 287

    CAS  Google Scholar 

  8. P.J. Sadler,Struct. Bonding (Berlin), 1976,29, 171

    Article  CAS  Google Scholar 

  9. F.E. Moore, R.J. Othmam and B. March,J. Amer. Pharm. Ass., 1951,15, 184

    Google Scholar 

  10. C.F. Shaw, G. Schmitz, H.O. Thompson and P. Witkiewicz,J. Inorg. Biochem., 1979,10, 317

    Article  CAS  Google Scholar 

  11. K. Brown, R.V. Parish and C.A. McAuliffe,J. Amer. Chem. Soc., 1981,103, 4943

    Article  CAS  Google Scholar 

  12. M.A. Mazid, M.T. Razi, P.J. Sadler, G.N. Greaves,et al.,J. Chem. Soc., Chem. Commun., 1980, 1261

  13. D.T. Hill, B.M. Sutton, A.A. Isab, M.T. Razi,et al., Inorg. Chem., 1983,22, 2936

    Article  CAS  Google Scholar 

  14. A.K.H. Ai-Sa’ady, CA. McAuliffe, K. Moss and R.V. Parish,J. Chem. Soc., Dalton Trans.,1984, 1609

  15. I.G. Dance,Inorg. Chim. Acta, 1977,25, L17

    Article  CAS  Google Scholar 

  16. I.G. Dance, L.J. Fitzpatrick, A.D. Rae and M.L. Scudder,Inorg. Chem., 1983,22, 3785

    Article  CAS  Google Scholar 

  17. I.G. Dance, L.J. Fitzpatrick and M.L. Scudder,Inorg. Chem., 1984,23, 2276

    Article  CAS  Google Scholar 

  18. R.C. Elder, K. Ludwig, J.N. Cooper and M.K. Eidsness,J. Amer. Chem. Soc., 1985,107, 5024

    Article  CAS  Google Scholar 

  19. S.R. Rudge, D. Perrett, A.J. Swannell and P.L. Drury,J. Rheum., 1984,11, 150

    CAS  Google Scholar 

  20. D.T. Hill and B.M. Sutton,Cryst. Struct Commun., 1980,9, 679

    CAS  Google Scholar 

  21. K. Tepperman, R. Finer, S. Donovan, R.C. Elder,et al., Science, 1984,225, 430

    Article  CAS  Google Scholar 

  22. A.P. Intoccia, T.L. Flanagan, D.T. Walz, L. Gutzail,et al., J. Rheumatol., 1982,9, (Suppl. 8), 90

    Google Scholar 

  23. S.M. Cottrill, H.L. Sharma, R.V. Parish and C.A. McAuliffe, (unpublished data)

  24. I. Jaffe,Ann. Rheum. Dis., 1963,27, 14

    Article  Google Scholar 

  25. F. Arrigoni-Martelli, E. Bramm and L. Binderup,Europ. J. Rheum. Inflamm., 1978,1, 197

    CAS  Google Scholar 

  26. E. Jellum, E. Munthe, G. Guldal and J. Aaseth,Ann. Rheum. Dis., 1980,39, 155

    Article  CAS  Google Scholar 

  27. E. Munthe, E. Jellum,Scand. J. Rheum., 1908, Suppl. 33, 21

  28. Seee.g. N.L. Gottleib,Scan. J. Rheum., 1984,10, (Suppl. 15);idem, Bull. Rheum. Dis., 1977,27, 912; A.J. Lewis and D.T. Walz,Prog. Med. Chem., 1982,19, 1; D.E. Fürst and S.H. Dromgoole,Clin. Rheumatol., 1984,3, (Suppl. 1), 17

  29. B. Vernon-Roberts, J.L. Dove, J.D. Jessop and W. Henderson,Ann. Rheum. Dis., 1976,35, 477

    Article  CAS  Google Scholar 

  30. R.C. Blodgett, M.A. Heuer and R. Peitrusko,Semin. Arth. Rheum., 1984,13, 25

    Google Scholar 

  31. R.C. Gerber, H.E. Paulus, R. Bluestone and M. Lederer,Arth. Rheum., 1972,15, 622

    Google Scholar 

  32. A. Lorber, R.L. Cohen C. Chang and H.E. Anderson,Arth. Rheum., 1968,11, 170

    Article  CAS  Google Scholar 

  33. G.G. Graham, T.M. Haavisto, H.M. Jones and C.D. Champion,Biochem. Pharm., 1984,33, 1257

    Article  CAS  Google Scholar 

  34. D. Lewis, H.A. Capell, C.J. McNeill, M.S. Iqbal,et al., Ann. Rhem. Dis., 1983,42, 566

    Article  CAS  Google Scholar 

  35. S.M. Pederson and P.M. Graabeek,Ann. Rhem. Dis., 1980,39, 576

    Article  Google Scholar 

  36. E.N. Ghadially, A.F. Ortschak and D.M. Mitchell,Ann. Rheum. Dis., 1976,35, 67

    Article  CAS  Google Scholar 

  37. D.T. Walz, D.E. Griswold, M.J. DiMartino and E.E. Bumbier,J. Rheumatol., 1979,6 (Suppl. 5), 56

    Google Scholar 

  38. D.T. Walz, M.J. DiMartino, D.E. Griswold, A.P. Intoccia and T.L. Flanagan,Amer. J. Med., 1983,74, 90

    Article  Google Scholar 

  39. A. Lorber,Agents and Actions, 1981, Suppl. 8, 539

  40. E.G. McQueen and P.W. Dykes,Ann. Rheum. Dis., 1969,28, 437; W.D. Block, O.H. Buchanan and R.H. Freyberg,J. Pharm. Exp. Theor., 1942,76, 355; N.L. Gottlieb, P.M. Smith and E.M. Smith,Arth. Rheum., 1972,15, 16; D. Kamel, D.H. Brown, J.M. Ottway, W.E. Smith,et al., Agents Actions, 1978,8, 546

    Article  CAS  Google Scholar 

  41. C.F. Shaw, N. Schaeffer-Memmel and D. Krawczak,J. Inorg. Biochem., 1986,26, 185

    Article  CAS  Google Scholar 

  42. F.N. Ghadially,J. Rheumatol., 1979, Suppl. 5, 45

  43. H. Nakamura and M. Igarashi,Ann. Rheum. Dis., 1977,36, 209

    Article  CAS  Google Scholar 

  44. R.C. Elder, M.K. Eidsness, M.J. Heeg, K.G. Tepperman,et al., Amer. Chem. Soc. Symp. Ser., 1983,209, 385

    CAS  Google Scholar 

  45. R.C. Elder,Proc. Symp. Bioinorg. Chem. Gold, SK&F Laboratories, Philadelphia, 1983, 124

  46. K.J. Lawson, C.J. Danpure and D.A. Fyfe,Biochem. Pharmacol., 1977,26, 2417

    Article  CAS  Google Scholar 

  47. N.C. Baenziger, K.M. Dittemore and J.R. Doyle,Inorg. Chem., 1974,13, 805

    Article  CAS  Google Scholar 

  48. U.C. Elder, E.H. Kelle-Zeiher, M. Onady and R.R. White,J. Chem. Soc., Chem. Commun., 1981, 900

  49. J.A. Muir, M.M. Muir and S. Arias,Acta Cryst., 1982,B38, 1318

    CAS  Google Scholar 

  50. J.A. Muir, M.M. Muir, S. Arias, C.F. Campana and S.K. Dwight,Acta Cryst., 1982,B38, 2047

    CAS  Google Scholar 

  51. J.A. Muir, M.M. Muir, S. Arias, P.G. Jones and G.M. Sheldrick, quoted by P.G. Jones,Gold Bull., 1983,16, 114

    Google Scholar 

  52. J.C. Hoffmann, R.S. Roth and A.R. Seidle,J. Amer. Chem. Soc., 1976,98, 4340; E.M. Kinsch and D.W. Stephan,Inorg. Chim. Acta, 1985,96, L87

    Article  Google Scholar 

  53. A.A. Isab and P.J. Sadler,J. Chem. Soc., Dalton Trans., 1982, 135

  54. C.F. Shaw,Proc. Symp. Bioinorg. Chem. Gold, SK&F Laboratories, Philadelphia, 1983, 98

    Google Scholar 

  55. P.A. Bates and J.M. Waters,Acta. Cryst., 1985,C41, 862

    CAS  Google Scholar 

  56. S.M. Cottrill, L.S. Moore, R.V. Parish and C.A. McAuliffe, (unpublished data)

  57. N.A. Malik, G. Otiko, M.T. Razi and P.J. Sadler,Proc. Symp. Bioinorg. Chem. Gold, SK&F Laboratories, Philadelphia, 1983, 82

    Google Scholar 

  58. H.H. Hull, R. Chang and L.J. Kaplan,Biochem. Biophys. Acta, 1975,400, 132

    CAS  Google Scholar 

  59. C.F. Shaw, N.A. Schaeffer, R.C. Elder and M.K. Eidsness,et al., J. Amer. Chem. Soc., 1984,106, 3511

    Article  CAS  Google Scholar 

  60. E. Jellum, E. Munthe, G. Guldal and J. Aaseth,Ann. Rheum. Dis., 1980,39, 155

    Article  CAS  Google Scholar 

  61. M.T. Coffer, C.F. Shaw, M.K. Eidsness, J.W. Watkins and R.C. Elder,Inorg. Chem., 1986,25, 333

    Article  Google Scholar 

  62. G. Lewis and C.F. Shaw,Inorg. Chem., 1986,25, 58

    Article  CAS  Google Scholar 

  63. G.G. Graham, J.R. Bales, M.C. Grootveld and P.J. Sadler,J. Inorg. Biochem., 1985,25, 163

    Article  CAS  Google Scholar 

  64. M.T. Razi, G. Otiko and P.J. Sadler,Amer. Chem. Soc. Symp. Ser., 1983,209, 371

    CAS  Google Scholar 

  65. J.E. Laib, C.F. Shaw, D.H. Petering, M.K. Eidsness,et al., Biochem., 1985,24, 1977

    Article  CAS  Google Scholar 

  66. C.F. Shaw and J.E. Laib,Inorg. Chim. Acta, 1986,123, 197

    Article  CAS  Google Scholar 

  67. A. Glennaset al., Abstr. 2nd Metallothionein Mtg., Zurich, 1985, 46;20th Great Lakes Regional Amer. Chem. Soc. Mtg., Milwaukee, 1986, (Abstr.) 205

  68. T.M. Simon, D.H. Kunishima, G.J. Vibert and A. Lorber,Cancer Res., 1981,41, 94

    CAS  Google Scholar 

  69. C.K. Mirabelli, R.K. Johnson, C.M. Sung, L. Faucette,et al., Cancer Res., 1985,45, 32

    CAS  Google Scholar 

  70. Nat. Cancer Inst., quoted by S.J. Berners-Price and P.J. Sadler in ‘Frontiers in Bioinorganic Chemistry’, A.V. Xavier (ed.), VCH Verlag., Weinheim, 1956, p. 376

    Google Scholar 

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Parish, R.V., Cottrill, S.M. Medicinal gold compounds. Gold Bull 20, 3–12 (1987). https://doi.org/10.1007/BF03214653

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