Abstract
Our retrospective PET and animal studies were conducted on a total of eight patients with normal testes and five male Sprague-Dawley rats. All the rats were necropsied at 60 minute post-injection of FDG, and the organs were removed and counted. The human testes were visualized on 60–70 minute FDG-PET images and whole- or partial-body images in all of the patients. The correlations between patient age over 50 years old and testis-to-muscle ratios, and patient age and SUVs were statistically significant, r = − 0.755, p < 10−6 (n = 7), r = − 0.900, p < 0.007 (n = 4), respectively. FDG uptake of the rat testes was 0.162 ± 0.004% kg injected dose/g (n = 5). The uptake was approximately 6.0 and 3.6 times as high as muscle and blood levels, respectively. In conclusion, there is substantial uptake of FDG into the normal testis which declines with age. The normal levels of FDG uptake in the testis relative to the patient’s age should be considered in the interpretation of FDG scans of the inguinal and lower pelvic regions.
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References
Wahl RL. Positron emission tomography: Application in oncology.In: Murray PC, Ell PJ, eds. Nuclear Medicine in Clinical and Treatment. Edinburgh, Churchill Livingstone, pp. 801–882, 1994.
Wahl RL. Positron emission tomography: Application in oncology.In: Henkin RE, Boles MA, Dillehay GL, et al., eds. Nuclear Medicine. St. Louis, Mosby, pp. 1524–1545, 1996.
Hoh CK, Hawkins RA, Glaspy JA, Dahlbom M, Tse NY, Hoffman EJ, et al. Cancer detection with whole-body PET using 2-[18F]fluoro-2-deoxy-D-glucose.J Comput Assist Tomogr 17: 582–589, 1993.
Toorongian SA, Mulholland GK, Jewett DM, Bachelor MA, Kilbourn MR. Routine production of 2-deoxy-2-[18F]fluoro-D-glucose by direct nucleophilic exchange on a quarternary 4-aminopyridinium resin.Int J Rad Appl Instrum 17: 273–279, 1990.
Sokoloff L. Circulation and metabolism of the brain.In: Siegel GJ, Albers RW, Katzman R, Agranoff BW, eds. Basic Neurochemistry. 2nd ed., Boston, Little, Brown, pp. 388–413, 1976.
DiChiro G, Brooks RA. PET-FDG of untreated and treated cerebral gliomas.J Nucl Med 29: 421–422, 1988.
Bell GI, Kayano T, Buse JB, Burant CF, Takeda J, Lin D, et al. Molecular biology of mammalian glucose transporters.Diabetes Care 13: 198–208, 1990.
Muecjler M. Facilitative glucose transporters.Eur J Biochem 219: 713–725, 1994.
Wahl RL, Henry CA, Ethier SP. Serum glucose: Effects on tumor and normal tissue accumulation of 2-[F-18]fluoro-2-deoxy-d-glucose in rodents with mammary carcinoma.Radiology 183: 643–647, 1992.
Gallagher BM, Ansari A, Atkins H, Casella V, Christman DR, Fowler JS, et al. Radiopharmaceuticals XXVII.18F-labeled 2-deoxy-2-fluoro-D-glucose as a radiopharmaceutical for measuring regional myocardial glucose metabolismin vivo: tissue distribution and imaging studies in animals.J Nucl Med 18: 990–996, 1977.
Jabour BA, Choi Y, Hoh CK, Rege SD, Soong JC, Lufkin RB, et al. Extracranial head and neck: PET imaging with 2-[F-18]fluoro-2-deoxy-d-glucose and MR imaging correlation.Radiology 186: 27–35, 1993.
Zasadny KR, Wahl RL. Standardized uptake values of normal tissues at PET with 2-[fiuorine-18]-fluoro-2-deoxy-d-glucose: variations with body weight and a method for correction.Radiology 189: 847–850, 1993.
Amrolia P, Sullivan MHF, Garside D, Baldwin SA, Cooke BA. An investigation of glucose uptake in relation to steroidogenesis in rat testis and tumour Leydig cells.Biochem J 249: 925–928, 1988.
Holmang A, Bjorntorp P. The effects of testosterone on insulin.Acta Physiol Scand 146: 505–510, 1992.
Burant CF, Takeda J, Brot-Laroche E, Bell GI, Davidson NO. Fructose transporter in human spermatozoa and small intestine is Glut5.J Biol Chem 267: 14523–14526, 1992.
Wahl RL, Zasadney KR, Cody R, Helvie M. FDG accumulation in normal breasts declines with aging.J Nucl Med 35 (suppl): 142p, 1994.
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Kosuda, S., Fisher, S., Kison, P.V. et al. Uptake of 2-deoxy-2-[18F]fluoro-d-glucose in the normal testis: Retrospective PET study and animal experiment. Ann Nucl Med 11, 195–199 (1997). https://doi.org/10.1007/BF03164763
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DOI: https://doi.org/10.1007/BF03164763