Abstract
The aim of our compartment modelling studies is the prognostication of the protective effectiveness of the stable iodine intaken to decrease the radiation damage of the thyroid resulting from accidental radioiodine incorporation. The protective capacity of stable iodine prophylaxis is investigated in relation to the daily iodine supply.
Calculations have been done according to Johnson’s modified version of Riggs iodine kinetics model with parameters taken from them and ICRP’s Reference Man. In this four-compartment model kinetics of the radioactive and of stable iodine is described by 10 differential equations. According to our model-analysis solutions of 5 equations can be given in analytical forms, thus only a 5-dimensional system should be integrated numerically. Method of Runge-Kutta-Fehlberg was used for this purpose. The radiation burden is characterized by the residence times /cumulative activities/ of 131-I in thyroid gland treated with stable iodine related to control subjects.
According to our results at iodine supply of a quarter of the normal dietary iodine intake (75 /ug/day) the residence times of 131-I in the thyroid gland are doubled and the protective effect of stable iodine given in the same large doses and at the same time-intervals are decreased by 30–50% in comparison with that at normal iodine supply. As another example the elevation of standard iodine supply by 50% leads to a 30% reduction of residence times with a 20% enhancement of protective effectiveness of stable iodine prophylaxis.
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Turai, I., Kanyár, B. Compartment modelling study of stable iodine prophylaxis in relation to the daily iodine supply. Acta Physica Hungarica 59, 43–46 (1986). https://doi.org/10.1007/BF03055183
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DOI: https://doi.org/10.1007/BF03055183