Summary
Study of swine indicates that post-traumatic SCh-induced hyperkalaemia is related not to the type of trauma per se but to trauma-induced abnormalities in muscle. Three groups of swine were studied: normal controls, thermal-trauma swine, and sciatic-section swine. The normal control and the thermal-trauma swine reacted similarly to SCh, with an immediate increase in arterial serum K of approximately 0.5 mEq/liter. Denervated swine responded to SCh with a significantly greater increase; simultaneous femoral venous samples indicated that the source of the K was the denervated leg. These findings are discussed in terms of the responses of human burn and trauma patients to SCh.
Résumé
Une étude sur des truies nous démontre que l’hyperkalémie produite par l’injection de succinylcholine chez l’animal traumatisé ne dépend pas du traumatisme luimême mais des anomalies produites dans le muscle par le traumatisme. Nous avons étudié trois groupes de truies: un groupe de contrôle: truies normales, un autre groupe avec un traumatisme par la chaleur et un autre, avec section du nerf sciatique. Les animaux du groupe de contrôle et du groupe traumatisme thermique ont réagi de la même façon à l’injection de la succinylcholine, cést-à-dire une augmentation immédiate du taux sérique de potassium de 0.5 mEq/litre. Les animaux du groupe au sciatique sectionné ont répondu à l’injection de succinylcholine par une augmentation beaucoup plus grande du taux de potassium; le prélèvement simultané d’échantillons dans les veines fémorales nous a permis de découvrir que la source de potassium venait du membre au nerf sectionné. Nous discutons ces résultats en songeant aux réponses à la succinylcholine chez les brûlés et les traumatisés humains.
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Additional information
Mayo Clinic and Mayo Foundation: Department of Anesthesiology, Rochester, Minnesota.
Read at the meeting of the Canadian Anaesthetists’ Society, Quebec City, Canada, June 27 to July 2, 1971.
This investigation was supported in part by Research Granthe-4881 from the National Insti
tutes of Health, Public Health Service.
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Gronert, G.A., Theye, R.A. Serum potassium changes after succinylcholine in swine with thermal trauma or sciatic nerve section. Canad. Anaesth. Soc. J. 18, 558–562 (1971). https://doi.org/10.1007/BF03026018
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DOI: https://doi.org/10.1007/BF03026018