Conclusion
The pharmacological study of levomeprormazine reveals analgesic and anaesthetic properties in accord with the physiopathogenesis of pain. Clinical studies showed that levomepromazine has a local anaesthetic action, a central analgesic action on the thalamic pain centre, an antihistamine action in accord with Lewis’ theory on histaminogenic impulses, and an effective neuroyegetative action.
All these antalgic properties are evident n the treatment of cancerous pains and neuritic pains and are beneficial in the treatment of rheumatic pains. Its anaesthetic properties enable prolonged surgery to be performed with a minimum of other anaesthetic agents. In the relief of postoperative pain, with levomepromazine the amount of narcotics used can be reduced by more than 80 per cent.
Sympathetic ganglion infiltration witti 0.3 per cent levomepromazine solution at pH 4.3 produces an immediate vasoplegic response.-When diluted in normal saline, it produces a positive but slower response.
We believe that the analgesic and anaesthetic aspects of levomepromazine should be emphasized and that the drug has a place in the relief of pain.
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References
Cailar, J. Du;Decourt, A.; &Rioux, J. Intérêt de la lévomépromazine (7044 R.P.) en anesthesiologie. Presse Médicale44 (Sept. 1959).
Cailar, J. Du;Vermette, M.;Rioux, J. ; &Herail, J. Une technique standard d’anesthésie veineuse sans barbiturique: intérêt de I’association ataralgésiante: pyrrolarpidol et lévomépromazine. Anesth. & Analg.4: 797–808 (Sept.-Oct. 1959).
Decourt, A. La lévomépromazine en anesthésiologie. Anesth. & Analg.4: 808–820 (Sept. Oct. 1959).
Laborit, G. Etude physico-biologique de la lévomépromazine chez l’homnjte. Anesth. & Analg.4: 820–833 (Sept.-Oct. 1959).,
Hazard, R. Actualités pharmacologiques, Troisième série, p. 183. Paris: Masson & Cie.
Guillaume, J.;DeSeze, S.; &Mazars, G. Chirurgie cérébrospinale de la douleur.
Paradis, B. La lévomépromazine en anesthésie. Anesth. & Analg.16: 185–193 (1959).
Paradis, B.;Plante, G.;Aubut, J.; &Tardif, A. La lévomépromazine (Nozinan ou 7044 R.P.) Etude clinique, pharmacologiqqe et biochimique portant sur 1000 observations. Laval Méd.28: No. 4 (Nov. 1959).
Paradis, B.;Lamontagne, A.;Gagne-Desr osiers, R.; &Lamarche, Y. Association Nozinan-Fluothane en anesthesie. Laval Méd.28: No. 3 (Oct. 1959).
RhôNE-Spécia-Poulenc (pub.) Applications di Nozinan en anesthésiologie.
Sigwaldet al. Le traitement du zona et des algies zostériennes-Etude des résultats obtenus avec la lévomépromazine. Thérapie14: 818–824 (1959).
Sigwaldet al. L’action anti-algique des phénothiazines. Thérapie14: 978–987 (1959).
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Paper iread before the Canadian Anaesthetists’ Socfety, Quebec Division, Chicoutimi, May 28, 1960.
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Paradis, B. Analgesic and. anaesthetic properties of levomepromazine (nozina®) (r.p.7044). Can. Anaes. Soc. J. 9, 153–160 (1962). https://doi.org/10.1007/BF03021257
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DOI: https://doi.org/10.1007/BF03021257