Summary and Conclusion
The blood level of histamine was measured in six control patients scheduled for elective surgery. In eleven patients the histamine blood level was measured before and five minutes after the rapid intravenous injection of 0.44 mg. per kg. body weight ofd-tubocurarine. There was no change in the histamine blood level of four patients, a rise in the histamine blood level of four patients, and a decrease in the histamine blood levels of three patients. The last group of patients all showed evidence of systolic hypotension, increased airway resistance, and skin erythema.
Histamine may be released from endogenous sources byd-tubocurarine. The significance of this release is determined by the sensitivity of the histamine effector cells and by the state of the histamine binding sites. When these are abnormal, such as in asthmatic or “ectopic” individuals, it is wise to use relaxants other thand-tubocurarine.
Résumé
Le taux d’histamine dans le sang fut mesuré chez six malades témoins devant subir une chirurgie élective. Chez onze malades, le taux d’histamine fut mesuré avant, et cinq minutes après l’injection rapide ded-tubocurarine par voie I.V., à raison de 0.44 mg./kg. de poids corporel. Il n’y eut aucun changement du taux d’histamine chez quatre malades; il y eut une élévation chez quatre autres malades, et une diminution chez trois malades. Chez ces derniers, on constata une hypotension systolique, une résistance augmentée du “airway,” et de l’érythème.
Lad- tubo peut provoquer la libération d’histamine à partir de sources endogènes. L’explication de cette libération nous serait donnée par la sensibilité des cellules effectrices de l’histamine, et par l’état des récepteurs d’histamine. Quand ceux-ci sont anormaux, comme chez les asthmatiques, il est sage de se servir de myorésolutifs autres que lad-tubocurarine. The work was supported by Research Grant No. H-1983 (C7) from the National Heart Institute, U.S. Public Health Service.
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Westgate, H.D., Van Bergen, F.H. Changes in histamine blood levels followingd-tubocurarine administration. Can. Anaes. Soc. J. 9, 497–503 (1962). https://doi.org/10.1007/BF03019190
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DOI: https://doi.org/10.1007/BF03019190