Summary
Althesin was compared with thiopentone in a double blind study of 200 patients undergoing gynaecological operations. Althesin in a dose of 0.05 ml/kg was found to be an excellent induction agent, virtually devoid of undesirable side effects; however, when used as the principal anaesthetic (supplemented only by 66 per cent nitrous oxide in oxygen), the incidence of disturbing movements was high. Recovery time from Althesin was one-third of that after thiopentone. The patients recovering from Althesin were remarkably clearheaded with a low incidence of “hangover“.
Résumé
L’althesin a été comparé au thiopentone dans une étude à double-insu chez 200 patientes subissant une intervention gynécologique. L’althesin, à des doses de 0.05 ml/kg s’est avéré être un excellent agent d’induction, pratiquement sans effet secondaire indésirable; cependant, lorsqu’il était employé comme agent anesthésique principal (avec N2O 66 pour cent et oxygène), l’incidence de mouvements ennuyeux était élevée. Le temps d’éveil après emploi d’althesin était du tiers de celui du thiopentone. Les patients étaient beaucoup plus lucides à l’éveil avec une incidence de “hangover“ minime.
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Campbell, D., Forrester, A.C., Miller, D.C., Hutton, L, Kennedy, J.A., Lawrie, T.D.V., Lorrimer, A.R., &McCall, D. A preliminary clinical study of CT 1341. Brit. J. Anaesth.43: 14 (1971).
Clarke, R.S.J., Montgomery, S.J., Dundee, J.W., &Bovill, J.G. Clinical studies if induction agents XXXIX: CT 1341, a new steroid anaesthetic. Brit. J. Anaesth.43: 947 (1971).
Swerdlow, M., Chakraborty, S.K., &Zahancir, M.A.H.M., A trial of CT 1341. Brit. J. Anaesth.43: 1075 (1971).
Savege, T.M., Foley, E.I., Coultas, R.J., Walton, B., Strunin, L., Simpson, B.R., &Scott, D.F. CT 1341: some effects in man. Cardiorespiratory, electroencephalographic and biochemical measurements. Brit. J. Anaesth.26: 402 (1971).
Clarke, R.S.J., Dundee, J.W., &Carson, I.W. Some aspects of the clinical pharmacology of Althesin. Postgrad. Med. J. Suppl. 2,48: 62 (1972).
Tammisto, T., Takki, S., Tigerstedt, I., &Kauste, A. A comparison of Althesin and Thiopentone in induction of anaesthesia. Brit. J. Anaesth.45: 100 (1973).
Symposium on steroid anaesthesia. Postgrad. Med. J. Suppl. 2,48: 9–139 (1972).
Glaxo Canada Ltd. Althesin (CT 1341) information for investigators.
Davis, B. &Pearce, D.R. An introduction to Althesin (CT 1341). Postgrad. Med. J. Suppl. 2,48: 13 (1972).
Child, K.J., Currie, J.P., Davis, B., Dodds, M.G., Pearce, D.R., Twissell, D.J. The pharmacological properties in animals of CT 1341 - a new steroid anaesthetic agent. Brit. J. Anaesth.43: 2 (1971).
Prys-Roberts, C., Foëx, P., &Biro, G.P. Cardiovascular responses of hypertensive patients to inductiin of anaesthesia with Althesin (CT 1341). Postgrad. Med. J. Suppl. 2,48: 80 (1972).
Savege, T.M., Foley, E.I., Ross, L., &Maxwell, M.P. A comparison of the cardiorespiratory effects during induction of anaesthesia of Althesin (CT 1341) with thiopentone and methohexitone. Postgrad. Med. J. Suppl. 2,48: 66 (1972).
Hannington-Kiff, J.G. Comparative recovery rates following inductiin of anaesthesia with Althesin and methohexitone in out-patients. Postgrad. Med. J. Suppl. 2,48: 116 (1972).
Warren, J.B. Althesin in the dental chair. Postgrad. Med. J. Suppl. 2,48: 130 (1972).
Swerdlow, M. Studies with Althesin - a new steroid anaesthetic. Postgrad. Med. J. Suppl. 2,48: 105 (1972).
Card, B., McCulloch, R.J., &Pratt, D.A.H. Tissue distribution of CT 1341 in the rat; an autoradiographic study. Postgrad. Med. J. Suppl. 2,48: 34 (1972).
Child, K.J., Gibson, W., Harnby, G., &Hart, J.W. Metabolism and excretiin of CT 1341 (Althesin) in the rat. Postgrad. Med. J. Suppl. 2,48: 37 (1972).
Gordh, T. The effect of Althesin on the heart insitu in the cat. Postgrad. Med. J. Suppl. 2,48: 31 (1972).
Foëx, P. &Prys-Roberts, C. Pulmonary haemodynamics and myocardial effects of Althesin in the goat. Postgrad. Med. J. Suppl. 2,48: 24 (1972).
Miller, D.C., Bradford, E.M.W., &Campbell, D. Haemodynamic effects of Althesin in poor-risk patients. Postgrad. Med. J. Suppl.48: 133 (1972).
Harrison, S.G.C. &Sellick, B.A. Cardiovascular effects of Althesin in patients with cardiac pathology. Preliminary communication. Brit. J. Anaesth.44: 1205 (1972).
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Obdrzalek, J. Althesin and thiopentone: A clinical comparison. Canad. Anaesth. Soc. J. 22, 601–606 (1975). https://doi.org/10.1007/BF03013412
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DOI: https://doi.org/10.1007/BF03013412