Abstract
The effects of halothane and isoflurane anaesthesia on myocardial injury in rabbits subjected to coronary artery ligation and subsequent reperfusion were analyzed. Although halothane and isoflurane (at inspired concentrations of 1.0 and 1.5 per cent, respectively) exerted comparable effects on cardiovascular status during ischaemic and reperfusion phases, greater preservation of subcellular integrity (as assessed by mitochondrial and sarcoplasmic reticular ATPase activities and myocardial ionic alterations) and a lower incidence of ventricular fibrillation and severe hypotension occurred with halothane. Our results indicate that in studies of experimental myocardial ischaemia anaesthetics may, independently of cardiovascular actions, influence the nature and extent of resulting injury, possibly by virtue of their differing effects on subcellular membrane systems.
Résumé
Les effets de l’anesthésie à l’halothane et l’isoflurane sur les lésions myocardiques chez les lapins ayant subi une ligature d’une artère coronaire et subséquemment reper-fusé ont été analysés. Même si l’halothane et l’isoflurane (des concentrations inspirées de 1.0 et 1.5 pour cent respectivement) ont presente des effets cardiovasculaires comparables durant l’ischémie et la reperfusion, on observa une plus grande préservation de l’intégrité des structures cellulaires (évalué par des altérations des mitochondries et de l’activité de la ATPase du reticulum sarcoplasmique ainsi que des alterations ioniques du myocarde) avec l’halothane. On observa aussi une incidence plus basse de fibrillation ventriculaire et a’hypotension sévère avec l’halothane. Nos résultats indiquent que lors d’éudes expérimentales sur l’ischémie myocardique, les agents anesthésiques peuvent indépendamment de leurs actions cardiovasculaires influencer la nature et l’étendue des lésions crées possiblement en vertue de leurs effets différents sur le système des membranes intra-cellulaires.
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This work was supported by a grant from the British Columbia Heart Foundation.
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Dolman, J., Godin, D.V. Myocardial ischaemic/ reperfusion injury in the anaesthetized rabbit: comparative effects of halothane and isoflurane. Can Anaesth Soc J 33, 443–452 (1986). https://doi.org/10.1007/BF03010969
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DOI: https://doi.org/10.1007/BF03010969