Abstract
Twelve mongrel dogs were randomized into two equal groups. Cervical, thoracic and lumbosacral spinal cord and spinal durai blood flows were measured using the radioactive microsphere technique. Blood flow determinations were made prior to and 20 and 40 minutes following lumbar subarachnoid injection of: (I) two per cent lidocaine (100 mg) or (2) two per cent lidocaine (100 mg) with 1/25,000 epinephrine (200 μg). Dogs receiving subarachnoid lidocaine demonstrated a decrease in mean arterial blood pressure of 23 per cent and 14 per cent (p < 0.05), while dogs receiving lidocaine with epinephrine had a decrease of 38 and 34 per cent (p < 0.05) at 20 and40 minutes respectively. Cardiac index was not significantly changed in either group. Lumbar subarachnoid lidocaine (100 mg) produced a rapid regional durai hyperemia (observed at 20 minutes postinjection) and a delayed regional spinal cord hyperemia (observed at 40 minutes postinjection) which were not observed following the addition of epinephrine (200 μg).
Résumé
Douze chiens bâtards ont été randomisés en deux groupes égaux. Utilisant des microsphères radioactives, les flots sanguins dans la moelle épiniére, dans les régions cervicales, thoraciques et lombosacrées ainsi que celles de la dure-mère ont été étudiés. La détermination des flots sanguins a été faite avant ainsi que de 20 et 40 minutes après injection sous-arachnoïdienne lombaire de: 1) deux pour cent de lidocaïne (100 mg) ou 2) deux pour cent de lidocaïne (100 mg) avec 1/25,000 épinephrine (200 iLg). Après injection sous-arachnoidienne, la pression artérielle moyenne a diminué significativement dans les deux groupes. Les chiens ayant recu une injection sous-arachnoidienne de lidocaïne ont démontré une diminution de 23 pour cent et de 14 pour cent du flot sanguin respectivement à 20 et 40 minutes. Les chiens ayant regu une injection sous-arachnoidienne de lidocaine avec épinephrine ont présenté une diminution de 38 pour cent et de 34 pour cent a 20 et 40 minutes respectivement. L’index cardiaque n’était pas changé significativement dans les deux groupes. Aucun changement significatif dans le flot sanguin de la dure-mère n ’ est survenu aprés injection sous-arachnoidienne de lidocaïneéavec ipinephrine. Les chiens ayant reçu une injection sous-arachnoidienne de lidocaine ont démontré une augmentation significative du flot sanguin de la moelle épiniére dans la région lombosacrée 40 minutes après I’injection. Le flot sanguin de la duremère dans la région lombosacrée a augmenté significativement à 20 et 40 minutes après injection. L’injection sous-arachnoïdienne lombaire de lidocaïne (100 mg) produit une hypérémie rapide dans la dure-mère ainsi qu’une hypérémie tardive régionale qui sera prévenue par I’addition d’épinephrine (200 µg).
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Supported by the University of Manitoba Faculty Fund, Grant Number 363-3111-04, and Astra Pharmaceuticals Canada Ltd.
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Kozody, R., Swartz, J., Palahniuk, R.J. et al. Spinal cord blood flow following subarachnoid lidocaine. Can Anaesth Soc J 32, 472–478 (1985). https://doi.org/10.1007/BF03010795
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DOI: https://doi.org/10.1007/BF03010795