Abstract
Clinical observations indicate that large oral doses of castor oil are effective in reducing the time of coma resulting from acute intoxication with lipophilic drugs. It has been further suggested that the rate of removal of these drugs from the body is increased by castor oil. In order to investigate the effect of castor oil on the disposition of lipophilic drugs, five dogs were given toxic doses of methyprylon by intravenous infusion. Each dog was treated with a large oral dose of castor oil in a cross-over fashion. No significant difference was observed in the sleep times of the dogs treated with castor oil, or in the methyprylon pharmacokinetics compared to controls.
It was concluded that castor oil does not affect the disposition of methyprylon.
Résumé
Des observations cliniques montrent que l’huile de ricin administrée à fortes doses par voie orale est efficace pour abréger la durée du coma causé par une intoxication aiguë aux agents lipophiliques. Il a de plus été suggéré que la vitesse d’élimination de ces agents est accélérée par l’huile de ricin. Notre travail effectué chez le chien avait pour but de vérifier cette assertion. A cette fin, cinq animaux ont reçu dans un premier temps des doses toxiques de methyprolon par voie intraveineuse, suivies de l’administration par voie orale de 10 ml/kg d’huile de ricin; l’expérience a été reprise sur chacun des chiens, une semaine plus tard, en omettant cette fois-ci la dose d’huile de ricin après le methyprolon. On n’a pas trouvé de différence significative entre les durées de sommeil et les données pharmakynétiques de methyprolon, et ceci, que les animaux aient reçu ou non de l’huile de ricin. Il est conclu que ce médicament ne modifie pas l’élimination du methyprolon.
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Gwilt, P.R., Pankaskie, M.C. & Mitala, J.J. The effect of oral castor oil on the disposition of methyprylon in intoxicated dogs. Can. Anaesth. Soc. J. 29, 381–383 (1982). https://doi.org/10.1007/BF03007530
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DOI: https://doi.org/10.1007/BF03007530