Abstract
Fifty healthy Nigerian surgical patients were given fazadinium bromide at a dose level of 10 mg- kg-1 while 30 other similar patients received 1.5 mg · kg-1. Anaesthesia was induced with either thiopentone or alfathesin. Tracheal intubation was satisfactorily accomplished after a mean of 55 seconds with the 1 mg· kg-1 dose and a mean of 32 seconds with the 1.5 mg· kg-1 dose. Duration of action of fazadinium 1 mg · kg-1 was a mean of 42 min (range 30 to 50 min) while the mean for 1.5 mg· kg-1 was 55 min (range 45 to 70 min). There was no significant difference between the thiopentone and alfathesin induction groups. Reversibility with neostigmine was excellent. Whereas the 1 mg ·kg-1 dose was satisfactory for normal regular intubation, the 1.5 mg · kg-1 dose is recommended for “crash” intubation. The administration of fazadinium was associated with a stable blood pressure and moderate sinus tachycerdia. No other side effects were seen.
Résumé
Cinquante patients nigé riens en bonne santé programmé s pour la chirurgie ont reçu du bromure de fazadinium à la dose de 1 mg · kg-1 alors que 30 autres patients supplé mentaires ont reçu 1.5 mg · kg-1. L’anesthésie a été mise en marche avec du thiopental ou de l’alfatésine. On a ré ussi l’intubation traché ale de façon satisfaisante après 55 secondes en moyenne avec la dose de 1 mg·kg-1 et en 32 secondes avec la dose de 1.5 mg·kg-1. La durée d’action du fazadinium à la dose de 1 mg · kg-1 était en moyenne de 42 minutes (entre 30 et 50 minutes) alors que la duré e moyenne pour la dose de 1.5 mg · kg-1 é tait de 55 minutes (entre 45 et 70 minutes). Il n’y a pas eu de diffé rence significative entre le groupe alfaté sine et le groupe thiopental. On recommande la dose de 1.0 mg · kg-1 pour l’intubation ré gulière alors qu’il est pré fé rable d’utiliser la dose de 1.5 mg · kg-1 pour l’intubation en catastrophe. Le renversement par la né ostigmine a été jugé comme très bonne dans tous les cas.
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Famewo, C.E. Clinical trial of fazadinium bromide (fazadon). Canad. Anaesth. Soc. J. 28, 149–152 (1981). https://doi.org/10.1007/BF03007259
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DOI: https://doi.org/10.1007/BF03007259