Summary
We have assessed the impact of thiopentone on the hypoxic ventilatory reflex, and on the responses to carbon dioxide and doxapram. Thiopentone sedation did not detectably alter any of these aspects of ventilatory control. Thiopentone anaesthesia reduced ventilation and the ventilatory responses to hypoxia, carbon dioxide and doxapram, all approximately in parallel. We conclude that, in contrast to halothane, thiopentone does not selectively reduce the ventilatory response to hypoxia. During light thiopentone anaesthesia, a reasonably brisk hypoxic response is present.
Résumé
Nous avons évalué ľinfluence du thiopenthal sur la réponse ventilatoire réflexe secondaire à ľhypoxie, à des variations de Pco2 et enfin au doxapram. Les doses sédatives de thiopenthal ne modifiaient pas significativement ces réflexes, alors que des doses anesthésiques de cet agent diminuaient de façon parallèle la ventilation ainsi que la ventilation réflexe secondaire à ľhypoxie, aux modifications de la CO2 et au doxapram. Nous concluons que le thiopenthal ne réduit pas de façon sélective la réponse ventilatoire réflexe à ľhypoxie; ľhalothane exerce, par contraste, une telle activité sélective. Sous anesthésie légère au thiopenthal, la réponse à ľhypoxie est assez vive.
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This work was supported by the Medical Research Council of Canada, Development Grant 150.
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Knill, R.L., Bright, S. & Manninen, P. Hypoxic ventilatory responses during thiopentone sedation and anaesthesia in man. Canad. Anaesth. Soc. J. 25, 366–372 (1978). https://doi.org/10.1007/BF03006565
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DOI: https://doi.org/10.1007/BF03006565