Summary
Enflurane sedation and anaesthesia in healthy fit subjects reduced ventilation and the response to carbon dioxide, hypoxaemia and a low dose of doxapram, all in a dose-related fashion. Comparing the three chemoreflexes tested, the response to hypoxaemia and doxapram were the more profoundly impaired; they were nearly totally abolished by anaesthesia. These effects of enflurane on chemoreflex activities are qualitatively similar to those previously observed with halothane.
Résumé
Ľenflurane à concentrations sédatives et anesthésiques produit une diminution de la ventilation et déprime la réponse réflexe à ľhypercarbie, à ľhypoxémie ainsi que celle à une petite dose de doxapram, le tout de façon proportionnelle à la concentration inhalée. Ce sont les réflexes à ľhypoxie et au doxapram qui sont les plus touchés: ils sont pratiquement abolis par ľanesthésie à ľenflurane. Ces effets sont qualitativement similaires à ceux observés avec ľhalothane.
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Knill, R.L., Manninen, P.H. & Clement, J.L. Ventilation and chemoreflexes during enflurane sedation and anaesthesia in man. Canad.Anaes.Soc.J. 26, 353–360 (1979). https://doi.org/10.1007/BF03006447
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DOI: https://doi.org/10.1007/BF03006447