Abstract
The purpose of this study was to compare the psychomotor recovery of patients sedated with either midazolam or Diazemuls using the digit symbol substitution test and the Trieger test. Sixty patients were allocated in random double-blind fashion to receive either midazolam or diazepam in oil emulsion (Diazemuls) as intravenous sedation for cataract surgery. Both groups received fentanyl 0.5 μg· kg−1 IV. Tests of cognition were performed by the patients prior to sedation and at half-hourly intervals for three hours after cataract surgery. In a dose ratio of 1:4, midazolam was found to produce better sedation but more prolonged recovery than Diazemuls. Anterograde amnesia was comparable in the two groups, while more patients in the Diazemuls group developed episodes of apnoea and venous irritation.
Résumé
Le but de cette étude est de comparer le réveil psychomoteur des patients sédationnés avec soit du midazolam soil du Diazemuls utilisant les tests de « The digit symbol substitution » et celui de «Trieger». Soixante patients ont été divisés au hasard et à double insu afin de recevoir soit du midazolam, soit du diazepam dans un émulsion huileuse (Diazemuls) pour une sédation intraveineuse pour une chirurgie de cataracte. Les deux groupes ont recu du fentanyl 0,5 μg · kg−1. Les tests ont été fails par les patients avant la sédation et à des intervalles de 30 minutes pour trois heures après la chirurgie de cataracte. Dans le rapport de dose de 1:4, le midazolam à été trouvé comme fournissant une meilleure sédation et un réveil plus prolongé que le Diazemuls. L’amnesie antérograde était cornparable dans les deux groupes, alors qu’un nombre plus élevé de patients dans le groupe Diazemuls à développé des épisodes d’apnée et une irritation veineuse.
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Chung, F., Cheng, D.C.H., Seyone, C. et al. A randomized comparison of midazolam and diazepam injectable emulsion in cataract surgery. Can J Anaesth 37, 528–533 (1990). https://doi.org/10.1007/BF03006320
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DOI: https://doi.org/10.1007/BF03006320