Summary
Methoxyflurane anaesthesia in dogs had no significant effect on time of onset or duration of ventricular arrhythmias produced by continuous infusion of epinephrine. It is concluded that methoxyflurane neither protects nor sensitizes the canine myocardium to epinephrine. It is suggested that methoxyflurane is the inhalation anaesthetic of choice when epinephrine is employed.
Résumé
Ľanesthésie au méthoxyflurane chez les chiens n’a pas eu ďeffet appréciable sur le moment du début ou sur la durée des arythmies ventriculaires produites par une infusion continue ďépinéphrine. On peut conclure que le méthoxyflurane ne protège ni ne sensibilise le myocarde des chiens à ľépinéphrine. On est ďavis que, parmi les anesthésiques par inhalations, de méthoxyflurane est ľanesthésique de choix lorsque ľépinéphrine est utilisée.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Orth, O. S.;Leigh, M. D.;Mellish, C. H.; &Stutzman, J. W. Action of Sympathomimetic Amines in Cyclopropane, Ether and Chloroform Anesthesia. J. Pharmacol. & Exper. Therap.67: 1 (1939).
Bamforth, B. J.;Siebecker, K. L.;Kraemer, R.; &Orth, O. S. Effect of Epinephrine on the Dog Heart during Methoxyflurane Anesthesia. Anesthesiology.22: 169 (1960).
Van Poznak, A. &Artusio, J. F., Jr. A Series of Fluorinated Ethers. Fed. Proc.19: 273 (1960).
North, W. C. &Knox, P. R. The Influence of Methoxyflurane upon the Cardiovascular Response to Epinephrine. Fed. Proc.20: 312 (1961).
Dobkin, A. B. &Israel, J. S. The Effect of sa 97, Perphenazine and Hydroxyzine on Epinephrine-induced Cardiac Arrythmias during Methoxyflurane Anaesthesia in Dogs. Canad. Anaesth. Soc. J.9: 36 (1962).
Israel, J. S.;Criswick, V. G.; &Dobkin, A. B. Effect of Epinephrine on Cardiac Rhythm during Anesthesia with Methoxyflurane (Penthrane) and Trifluoroethyl Vinyl Ether (Fluoromar). Acta Anaesth. Scandinav.6: 7 (1962).
Hudon, F. Methoxyflurane. Canad. Anaesth. Soc. J.8: 544 (1961).
Andersen, N. &Andersen, E. W. Methoxyflurane. Acta Anaesth. Scandinav.5: 179 (1961).
Kaveney, R. E. &Wasmuth, C. E. Methoxyflurane: A Clinical Evaluation of Its Effects, Based on Five Hundred Cases. Cleveland Clin. Quart.29: 148 (1962).
Jacques, A. &Hudon, F. Effect of Epinephrine on the Human Heart during Methoxyflurane Anaesthesia. Canad. Anaesth. Soc. J.10: 53 (1963).
McGarry, P. M. F. Clinical Experience with Methoxyflurane (Penthrane). Canad. Anaesth. Soc. J.10: 380 (1963).
Jarman, R. &Edghill, H. B. Methoxyflurane (Penthrane). Anaesthesia.18: 265 (1963).
Erickson, J. C. III;Krumperman, L. W.; &Ronis, M. L. Methoxyflurane Anaesthesia for Middle Ear Surgery. Arch. Otolaryngol.80: 69 (1964).
North, W. C. &Stephen, L. R. A Second Look at Methoxyflurane: Four Years of Experience. Anesth. & Analg.45: 117 (1966).
Arens, J. F. Methoxyflurane and Epinephrine Administered Simultaneously. Anesth. & Analg.47: 391 (1968).
Meek, W. J.;Hathaway, H. R.; &Orth, O. S. The Effects of Ether, Chloroform and Cyclopropane on Cardiac Automaticity. J. Pharmacol. Exper. Therap.61: 240 (1937).
Cohen, G.;Holland, B.;Sha, J.; &Goldenberg, M. Plasma Concentrations of Epinephrine and Norepinephrine during Intravenous Infusion in Man. J. Clin. Invest.38: 1935 (1959).
Israel, J. S.;Dobkin, A. B.; &Robidoux, H. J. The Effect of Sympathetic Blockade or Hyperventilation on Epinephrine-induced Cardiac Arrythmias during Anaesthesia with Halothane and Methoxyflurane. Canad. Anaesth. Soc. J.9: 125 (1962).
Matteo, R. S.;Katz, R. L.; &Papper, E. M. The Injection of Epinephrine during General Anesthesia with Halogenated Hydrocarbons and Cyclopropane in Man: I. Trichlorethylene. Anesthesiology.23: 360 (1962).
Katz, R. L.;Matteo, R. S.; &Papper, E. M. Injection of Epinephrine during General Anesthesia with Halogenated Hydrocarbons and Cyclopropane in Man: II. Halothane. Anesthesiology,23: 597 (1962).
Matteo, R. S.;Katz, R. L.; &Papper, E. M. Injection of Epinephrine during General Anesthesia with Halogenated Hydrocarbons and Cyclopropane in Man: III. Cyclopropane. Anesthesiology.24: 327 (1963).
Author information
Authors and Affiliations
Additional information
Dr. Burleigh was a medical student research fellow while carrying out this research.
Rights and permissions
About this article
Cite this article
Burleigh, B.W., Greene, N.M. Effect of methoxyflurane on epinephrine-induced ventricular arrhythmias. Can. Anaesth. Soc. J. 17, 341–346 (1970). https://doi.org/10.1007/BF03004697
Issue Date:
DOI: https://doi.org/10.1007/BF03004697