Summary
A surgical patient receiving lithium carbonate therapy is presented, in whom the use of the non-depolarizing muscle relaxant pancuronium bromide produced prolonged neuromuscular blockade. Possible mechanism of action involves impaired ACH synthesis and release. The physiology and pharmacology of lithium bromide are discussed.
Résumé
Nous présentons un cas de chirurgie où le malade recevait du carbonate de lithium, chez qui le bromure de pancuronium, un myorésolutif non dépolarisant, a produit un blocage neuromusculaire prolongé. Le mécanisme ďaction possible implique la synthèse et la libération de ľacétylcholine. Nous discutons la physiologie et la pharmacologie du bromure de lithium.
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Baastrup, P.C. &Schon, M. Lithium as a prophylactic agent. Its effect against recurrent depressions and manic-depressive psychosis. Arch. Gen. Psychiat. (Chicago).16: 162–172 (1967).
Angst, J., Dittrich, A., &Goof, P. Course of endogenous affective psychosis and its modification by prophylactic administration of imipramine and lithium. Int. Pharmacophychiat.2: 1–11 (1969).
Schose, M. Lithium in psychiatric therapy and phophylaxis. J. Psychiat. Res.6: 67–95 (1968).
Gershon, S. Lithium in mania. Clin. Pharmacol. Ther.11: 168–187 (1970).
Maggs, R. Treatment of manic illnesses with Lithium carbonate. Brit. J. Psychiat.109: 56–65 (1963).
Noyes, R.,Jr. Lithium carbonate: a review. Dis. Neur. Syst.30: 318–21 (1969).
Gershon, S. Lithium in mania. Clinical Pharm. and Ther.11: 168–185 (1970).
Gergis, S.D. Effect of pancuronium bromide on acethycholine release. Proc. Soc. Exp. Biol. Med.139: 74–76 (1972).
Sohn, Y.J. &Aldrete, J. A. Prejunctional effects of pancuronium bromide at the cat soleus neuromuscular junction. Fed. Proc. Fed. Amer. Soc. Exp. Biol.30: 557 (1971).
Foldes, F.F., Klonymus, D.H., Maisel, W., Sciammas, F., &Pan, T. Studies of pancuronium in conscious and anesthetized man. Anesthesiology35: 496–503 (1971).
Vizi, E.S. Illes, P.,Ronai, A., &Knoll, J. The effect of lithium on acetylcholine release and synthesis. Neuropharm.11: 521–530 (1972).
Paton, W.D.M., Vizi, E.S., &Far, O. The mechanism of acetylcholine release from parasympathetic nerves. J. Physiol. Lon.215: 819–848 (1971).
Katz, R., Chase, N., &Kapin, I.J. Evoked release of norepinephrine and serotonine from brain slices: inhibition by lithium. Science, N.Y.162: 466–467 (1968).
Platman, S., Rohrlich, J., &Fieve, R. Absorption and excretion of lithium in manicdepressive disease. Dis. Nerv. Syst.29: 733–38 (1968).
Allgen, L.G. Laboratory experience of lithium toxicity in man. Acta psychiat. Scand.207: 9–104 (1969).
Platman, S.R. &Fieve, R.R. Lithium retention and excretion. The effect of sodium and fluid intake. Arch. Gen. Psychiat. (Chicago)20: 285–289 (1969).
Walts, L.F. &Dillon, J.B. Deviations of action of ďtubocurarine and gallamine. Anesthesiology29: 499–504 (1968).
Walts, L.F., Lebowitz, M., &Dillon, J.B. The effect of ventilation on the action of tubocurarine and gallamine. Brit. J. Anesth.39: 845–849 (1967).
Norman, J., Katz, R.L., &Seed, R.F. Neuromuscular blocking action of pancuronium in man.42: 702–709 (1970).
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Borden, H., Clarke, M.T. & Katz, H. The use of pancuronium bromide in patients receiving lithium carbonate. Can. Anaesth. Soc. J. 21, 79–82 (1974). https://doi.org/10.1007/BF03004581
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DOI: https://doi.org/10.1007/BF03004581