Summary
This study was undertaken in an attempt to resolve the contradictions between our previous findings in dogs regarding the anti-emetic properties of trimethoxy-benzamide and the findings of Purkis regarding its properties in man.
From these further investigations it is clear that a reversal effect does not occur when large doses of trimethoxybenzamide are administered. The discrepancies are rather due to the fact that the therapeutic effect of trimethoxybenzamide is very short, whereas the effect of thiethylperazine and perphenazine is much more prolonged.
The difference between our original results and Purkis’s can now be explained on the basis of the more prolonged observation of patients carried out by Purkis, as opposed to our acute experiments in dogs, when only the presence or absence of protection to a single stimulus was recorded.
RéSUMé
Nous avons entrepris cette étude pour essayer de résoudre les contradictions entre nos résultats antérieurs chez le chien concernant les propriétés antiémétiques du trimethoxybenzamide et ceux que le docteur Purkis a obtenu chez l’homme.
A la suite de ces dernières recherches, il nous semble évident qu’il ne survient pas d’effet renversé lorsque nous administrons de fortes doses de trimethoxybenzamide. Il serait plausible que les différences soient attribuables plutôt au fait que l’effet thérapeutique du trimethoxybenzamide est court alors que celui du thiéthylperazine et de la perphenazine est beaucoup plus long.
La différence des résultats entre les observations de Purkis et les nôtres peuvent s’expliquer sur la base d’une observation plus longue sur les malades de Purkis en comparaison avec une expérience rapide sur nos chiens alors que nous tenions compte seulement de la présence ou de l’absence de protection à un seul stimulus..
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References
Wyant, Gordon M. AComparative Study of Eleven Anti-Emetic Drugs in Dogs. Canad.. Anaesth. Soc. J.9: 399 (1962).
Purkis, Ian E. The Action of Thiethylperazine (Torecan®), a New Anti-Emetic, Compared with Perphenazine (Trilafon®), Trimethoxybenzamide (Tigan®), and a Placebo in the Suppression of Postanaesthetic Nausea and Vomiting. Canad. Anaesth. Soc. J.12: 595 (1965).
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Dr. Tan was a Research Fellow and Mr. Gelmon a summer student in the Department of Anaesthesia and as such carried out work on Parts A and B respectively
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Tan, R.G.B., Gelmon, L.J. & Wyant, G.M. Further studies of three anti-emetics in common use. Can. Anaes. Soc. J. 13, 611–615 (1966). https://doi.org/10.1007/BF03002231
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DOI: https://doi.org/10.1007/BF03002231