Summary
Specimens were obtained of gastric, duodenal and jejunal contents under normal physiologic conditions and their reactions were determined in the fasting state and after various test meals, before and after draining the pancreatic secretion to the outside of the body. The production of a pancreatic fistula caused no change in the reaction of the gastric content during fasting or after the various types of test meal used in the research. However, differences in the reaction of the duodenal content were observed after establishing a pancreatic fistula. Although the range of variation during fasting was quite within normal limits in the two conditions, low determinations were more frequently obtained for the animal with a pancreatic fistula. Protein and carbohydrate meals caused a more rapid decrease of the pH, and the reaction was usually maintained at a decreased level for a longer period before returning toward neutrality than was found before elimination of the pancreatic secretion. These same changes were also observed to a lesser degree with the jejunal content, but only after a protein diet. A comparison of the results following the production of a pancreatic fistula and evulsion of the pancreatic ducts revealed a few more acid determinations in the former after protein and carbohydrate diets. The distinction, however, was slight and should not be emphasized.
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Elman, Robert and McCaughan, J. M.: On the collection of the entire external secretion of the pancreas under sterile conditions and the fatal effect of total loss of pancreatic juice.Jour. Exper. Med., 45:561–570, March, 1927.
McCaughan, J. M.: Experimental studies of the external secretion of the pancreas with special reference to the effect of its complete loss by permanent pancreatic fistula. I. The coincident changes in the chemistry of the blood. II. The mechanism of death.Am. Jour. Physiol., 97:459–466, June, 1931.
Mann, F. C., and Bollman, J. L.: A method for making a satisfactory fistula at any level of the gastro-intestinal tract.Ann. Surg., 93:794–797, March, 1931.
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Portion of abstract of thesis submitted to the Faculty of the Graduate School of the University of Minnesota in Partial fulfillment of the requirements for the degree of Ph. D. in Surgery.
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Hoerner, M.T. The effect of exclusion of the pancreatic secretion by a pancreatic fistula on the reaction of the gastric, duodenal and jejunal contents. American Journal of Digestive Diseases and Nutrition 2, 298–300 (1935). https://doi.org/10.1007/BF03000810
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DOI: https://doi.org/10.1007/BF03000810