Summary and conclusions
1. The hippuric acid test was used in a series of 77 cases. The results indicate that there may be a marked reduction in the detoxifying ability of the liver before any of the clinical signs of hepatic disease can be detected.
2. The simultaneous determination of the urea clearance increases the value of the hippuric acid test.
3. The ether extraction method with the formol titration is the most practical as well as the most accurate method of determining the hippuric acid in the urine.
4. The combined urea clearance and hippuric acid test is a reliable and valuable adjunct in the study of hepatic disease.
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From the Lilly Laboratories for Clinical Research and the Department of Medicine, Indianapolis City Hospital.
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Kohlstaedt, K.G., Helmer, O.M. A study of the hippuric acid excretion as a test of hepatic function. American Journal of Digestive Diseases and Nutrition 3, 459–466 (1936). https://doi.org/10.1007/BF03000730
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DOI: https://doi.org/10.1007/BF03000730