Conclusions
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1.
The employment of a dose of 5 mg. of bromsulphthalein per kilogram of body weight yields a higher percentage of positive results than does that of a dose of 2 mg., and at the same time the larger dose does not overtax the excretory function of the liver.
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2.
The blood secured 30 minutes after the injection of the 5 mg. dose contains the dye more frequently than that secured after 60 minutes, and the 60-minute specimen adds nothing to the diagnostic value of the test.
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3.
The retention of any of the dye in the blood 30 minutes after the injection of a 5 mg. dose should be regarded as an indication of impaired hepatic excretion.
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4.
The technique, as used by Israel and Reinhold, that requires a 5 mg. dose of the dye and a single specimen of blood, secured after 30 minutes, may be regarded as the most satisfactory of the suggested modifications of the bromsulphthalein test.
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From the Gastro-Intestinal Section (Kinsey-Thomas Foundation) of the Medical Clinic, Hospital of the University of Pennsylvania
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Helm, J.D., Machella, T.E. The significance of dosage and time factors on the value of the bromsulphthalein test for liver function. Jour. D. D. 9, 141–143 (1942). https://doi.org/10.1007/BF02997305
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DOI: https://doi.org/10.1007/BF02997305