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Multifocalité du carcinome épidermoïde sur les voies digestive supérieure et respiratoire distale: technicité du diagnostic endoscopique

Multiple squamous cell carcinoma of the upper digestive and lower respiratory tracts: methodology of endoscopic screening

  • Published:
Acta Endoscopica

Résumé

L'étude porte sur 951 porteurs d'un cancer primaire bucco-pharyngo-laryngé, et révèle un taux de multifocalité du carcinome épidermoïde sur les voies digestive supérieure (bouche-pharynx-œsophage) et aérienne distale (larynx-trachée-bronches) s'élevant à 14,5%. Les secondes localisations peuvent être simultanées (6,4%) ou successives (8,1%) à la découverte du premier cancer: dès la deuxième année du follow-up leur incidence dépasse celle des récidives. Elles se localisent tant au niveau ORL (8,5%) qu'œsophagien (3%) ou bronchique (3%). Le cancer du voile présente un taux de multifocalité particulièrement élevé (51%). Les auteurs décrivent un type d'endoscopie de dépistage (bucco-pharyngo-œsophago-laryngo-trachéo-bronchoscopie) dont la fiabilité repose sur une technicité spécifique d'une part, et sur la connaissance des caractéristiques propres aux secondes localisations d'autre part. Ce dépistage systématique permet de détecter les tumeurs secondaires à un stade le plus souvent précoce et encore asymptomatique.

Summary

This study concerns 951 patients with primary bucco-pharyngo-laryngeal cancers and reports a 14,5% rate of multiple foci epidermoid cancer of the upper digestive (mouth-pharynx-esophagus) and lower respiratory (larynx-trachea-bronchi) tracts. The second site tumors may occur simultaneously with the primary cancer (6,4%), or follow at a variable interval (8,1%). After two years of follow-up, their incidence rate is greater than the recurrence rate. They can occur in the E.N.T. region (8,5%), as well as in the esophagus (3%) or in the bronchi (3%). Cancer of the soft palate presents a particularly high multiple tumor rate (51%). The authors describe an endoscopic screening procedure (bucco-pharyngo-esophago-laryngo-tracheo-bronchoscopy) whose reliability depends on specific techniques as well as knowledge of the particular characteristics of second primary malignancies. This systematic screening allows early detection of these second primaries when they are most frequently asymptomatic.

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Bibliographie

  1. ABRAMSON A.L., PARISIER S.C., ZAMANSKY M.J., SULKA M. — Distant metastases from carcinoma of the larynx.Laryngoscope (St-Louis) 1971,81, 1503–1511.

    CAS  Google Scholar 

  2. ANDRIEU-GUITRANCOURT J., BROSSARD-LEGRAND M., HAPPICH J.L., LAMY J.M. — Endoscopie systématique de l'œsophage au cours des cancers buccaux, pharyngés et laryngés.Ann. Oto-Laryng., Paris, 1975,92, 659–666.

    Google Scholar 

  3. AUERBACH O., GERE B., FORMAN J. and al. — Changes in bronchial epithelium in relation to smoking and cancer of the lung: report of progress.New Engl. J. Med., 1957,256, 97–104.

    PubMed  CAS  Google Scholar 

  4. BERG J.W., SCHOTTENFELD D., RITTER F. — Incidence of multiple primary cancers. III. Cancers of the respiratory and upper digestive system as multiple primary cancers.J. Nat. Cancer Inst., 1970,44, 263–274.

    PubMed  CAS  Google Scholar 

  5. BILROTH T. — Die allgemeine chirurgische Pathologie und Therapie.14 Aufl., Berlin, G. Reimer, 1889, p. 908.

    Google Scholar 

  6. BRENDER E. — Contribution à l'étude des cancers multiples, simultanés et successifs, des voies aéro-digestives supérieures.Thèse Méd., Paris, 1976.

  7. CACHIN Y. — Cancers multiples concomitants des voies aéro-digestives supérieures.J. Fr. Otorhino-laryngol., 1972,3, 667–689.

    Google Scholar 

  8. CACHIN Y., BLACHE R., TRAN-BA-HUY P. — Bilan de l'autopsie de 100 malades porteurs de cancers des voies aéro-digestives supérieures. (Institut Gustave-Roussy, 1967–1968).Ann. Oto-Laryngol. (Paris), 1973,90, 275–283.

    CAS  Google Scholar 

  9. CAHAN W.G. — Multiple primary cancers of the lung, esophagus, and other sites.Cancer, 1977,40, 1954–1960.

    Article  PubMed  CAS  Google Scholar 

  10. CASTIGLIANO S.G. — Influence of continued smoking on the incidence of second primary cancers involving mouth, pharynx, and larynx.J. Amer. Dent. Assoc., 1968,77, 580–585.

    CAS  Google Scholar 

  11. DARGENT M., NOEL P., PIERLUCA P. — Résultats d'une étude nécropsique de la muqueuse œsophagienne chez les sujets ayant présenté des cancers de la sphère oro-pharyngo-laryngée.Bull. Acad. Nat. Méd., 1972,156, 408–415.

    PubMed  CAS  Google Scholar 

  12. DEMAILLE A., ADENIS L., GODEFROY-VENDEVILLE Y., VERHAEGHE M., VANLERBERGHE J. — Les cancers primitifs multiples (A propos de 379 observations).Lille Méd., 1971,16, 799–825.

    PubMed  CAS  Google Scholar 

  13. EPSTEIN S.S., PAYNE P.M., SHAW H.J. — Multiple primary malignant neoplasms in the air and upper food passages.Cancer, 1960,13, 137–145.

    Article  PubMed  CAS  Google Scholar 

  14. FAUVET J., CHAVY A., PIET R. — Les cancers primitifs multiples.Rev. Prat., 1964,14, 2149–2174.

    PubMed  CAS  Google Scholar 

  15. FERLITO A., DI BONITO L. — Primary cancer of the larynx associated with primary lung cancer. Report of 21 cases, 14 with autopsy findings and 7 biopsies.ORL, 1976,38, 230–245.

    Article  PubMed  CAS  Google Scholar 

  16. FONTANA R.S., SANDERSON D.R. and al — The Mayo lung project for early detection and localization of bronchogenic carcinoma: a status report.Chest., 1975,67, 511–521.

    Article  CAS  PubMed  Google Scholar 

  17. GARLAND L.H. and al. — The apparent site of origin of carcinoma of the lung.Radiology, 1962,78, 1–11.

    PubMed  CAS  Google Scholar 

  18. GOLDSHER M., BARTAL A., ELIACHAR I., ROBINSON E. — Laryngeal carcinoma associated with multiple additional primary tumors.Arch. Otolaryngol. 1977,103, 550–552.

    PubMed  CAS  Google Scholar 

  19. HAGUET J.-F., POULICHET J.-P., BRASNU D. — Cancers pharyngo-laryngés métastases pulmonaires et cancers bronchiques primitifs.Ann. Oto-Laryng. (Paris), 1977,94, 583–597.

    CAS  Google Scholar 

  20. HOLINGER P.H., JOHNSTON K.G., JENSIK R.J., HURZELER D. — Laryngeal and bronchial cancer. A study of double primary malignancy.Ann. Otol. (St. Louis), 1961,70, 475–489.

    CAS  Google Scholar 

  21. JUNOD B., PASCHE R. — Etio-épidémiologie des cancers de la bouche et du pharynx en Suisse.Schweiz. Med. Wschr., 1978,108, 882–887.

    PubMed  CAS  Google Scholar 

  22. JUSSAWALLA D.J., DESHPANDE V.A. — Evaluation of cancer risk in tobacco chewers and smokers: an epidemiologic assessment.Cancer, 1971,28, 244–252.

    Article  PubMed  CAS  Google Scholar 

  23. KOEHLER R.E., MOSS A.A., MARGULIS A.R. — Early radiographic manifestations of carcinoma of the esophagus.Radiology, 1976,119, 1–5.

    PubMed  CAS  Google Scholar 

  24. LAWSON W., SOM M. — Second primary cancer after irradiation of laryngeal cancer.Ann. Otol., 1975,84, 771–775.

    CAS  Google Scholar 

  25. LEDERMANN M. — The anatomy of cancer with special reference to tumor of the upper air and food passages.J. Laryngol. Otol., 1964,78, 181–208.

    Article  Google Scholar 

  26. LUND C.C. — Second primary cancer in cases of cancer of buccal mucosa: a mathematical study of susceptibility to cancer.New Engl. J. Med., 1933,209, 1144–1152.

    Google Scholar 

  27. MARSCH B.R. — Bronchoscopy for early lung cancer.World Congress on bronchoscopy, Tokyo, 1978.

  28. MASHBERG A., MORRISSEY J.B., GARFINKEL L. — A study of the appearance of early asymptomatic squamous cell carcinoma.Cancer, 1973,32, 1436–1445.

    Article  PubMed  CAS  Google Scholar 

  29. MOERTEL C.G. — Multiple primary malignant neoplasms: III. Tumors of multicentric origin.Cancer, 1961,14, 238–248.

    Article  Google Scholar 

  30. MOERTEL Ch. — Multiple primary malignant neoplasms, historical perspectives.Cancer, 1977,40, 1786–1792.

    Article  PubMed  CAS  Google Scholar 

  31. MONNIER P., CRAUSAZ P.H. — L'apport de l'endoscopie dans le diagnostic du cancer bronchique.Rev. Méd. Suisse Romande, 1979,99, 499–508.

    PubMed  CAS  Google Scholar 

  32. MONNIER P., SAVARY M., PASCHE R. — Intraepithelial carcinoma of the oesophagus: endoscopic morphology. A paraître dansEndoscopy.

  33. MOORE C. — Anatomic origin and location of oral cancer.Ann. Surg., 1967,114, 510–513.

    Article  CAS  Google Scholar 

  34. MOORE C. — Cigarette smoking and cancer of the mouth, pharynx, and larynx; a continuing study.J.A.M.A., 1971,218, 553–558.

    PubMed  CAS  Google Scholar 

  35. MOUNIER-KUHN P., GAILLARD J., REBATTU J.P., JAKUBOWICZ B. — Statistique des cancers multiples à la clinique oto-rhino-laryngologique de Lyon de 1950 à 1962.J. Fr. Oto-rhinolaryngol., 1963,12, 627–652.

    Google Scholar 

  36. PELLONI S. — Doppelkarzinome in Larynx und Lungen.Schweiz. Med. Wschr., 1975,105, 844–848.

    PubMed  CAS  Google Scholar 

  37. PENN I. — Second malignant neoplasms associated with immunosuppressive medications.Cancer, 1976,37, 1024–1032.

    Article  PubMed  CAS  Google Scholar 

  38. PERRY L.B., SANDERSON D.R. — Anesthesia for prolonged bronchoscopy.Ann. Thorac. Surg., 1975,19, 248–253.

    Article  PubMed  CAS  Google Scholar 

  39. PIERON R., BLANCHE J.M. — A propos de dix observations de proliférations malignes multiples.Sem. Hôp. Paris, 1977,53, 369–375.

    PubMed  CAS  Google Scholar 

  40. PRADOURA J.P., JAUSSERAN M., COQUIN J.Y., SENECHAL B., COLONNA D'ISTRIA J. — Endoscopie et double localisation néoplasique en O.R.L. 76e Congrès franç. d'O.R.L., compte rendu des séances, éd. Arnette, Paris, 1979, 247–257.

    Google Scholar 

  41. ROTHMAN K., KELLER A. — The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx.J. Chron. Dis., 1972,25, 711–716.

    Article  PubMed  CAS  Google Scholar 

  42. SAKULA A. — Multiple primary carcinomas of respiratory tract: primary carcinoma of larynx followed by primary carcinomas involving two lungs consecutively.Brit. J. Dis. Chest., 1974,68, 128–136.

    Article  PubMed  CAS  Google Scholar 

  43. SAVARY M. — Les états précancéreux de l'œsophage.Méd. et Hyg., 1976,34, 1285–1288.

    Google Scholar 

  44. SAVARY M., CRAUSAZ P.-H., MONNIER P. — La place de l'endoscopie totale aéro-digestive supérieure en cancérologie.Schweiz. Med. Wschr., 1979,109, 838–840.

    PubMed  CAS  Google Scholar 

  45. SAVARY M., PASCHE R., MONNIER P. — Cancer aéro-digestif supérieur: le médecin praticien et le médecin spécialiste face au problème du diagnostic précoce.Rev. Méd. Suisse Romande, 1979,99, 487–497.

    PubMed  CAS  Google Scholar 

  46. SCHOENBERG B.S. — Multiple primary neoplasms. In «Persons at high risk of cancer», Academic Press, New York, 1975, pp. 103–120.

    Google Scholar 

  47. SCHOENBERG B.S. — Multiple primary malignant neoplasms: the Connecticut experience 1935–1964.Springer-Verlag, New York, 1977.

    Google Scholar 

  48. SCHOTTENFELD D., GANTT R.C., WYNDER E.L. — The role of alcohol and tobacco in multiple primary cancers of the upper digestive system, larynx and lung: a prospective study.Prev. Med., 1974,3, 277–293.

    Article  PubMed  CAS  Google Scholar 

  49. SERROU B., DUBOIS J.-B., ROMIEU Cl. — L'immunodépression. Son rôle favorisant dans l'apparition des cancers multiples.Nouv. Presse méd., 1974,3, 1369–1371.

    PubMed  CAS  Google Scholar 

  50. SHARP G.S., BULLOCK W.K., HELSPER J.T. — Multiple oral carcinoma.Cancer, 1961,14, 512–516.

    Article  Google Scholar 

  51. SLAUGHTER D.P., SOUTHWICK H.W., SMEJKAL W. — «Field cancerization» in oral stratified squamous epithelium. Clinical implications of multicentric origin.Cancer, 1953,6, 963–968.

    Article  PubMed  CAS  Google Scholar 

  52. STEINER W. — Techniques of diagnostic and operative endoscopy of the head and neck (Part 1).Endoscopy, 1979,11, 51–59.

    Article  PubMed  CAS  Google Scholar 

  53. SUEMASU K., SHIMOSATO Y., ISHIKAWA S. — Multiple minute cancers of major bronchi. A case report.J. Thorac. Cardiovasc. Surg., 1974,68, 664–672.

    PubMed  CAS  Google Scholar 

  54. TARPLEY J.L., POTVIN C., CHRETIEN P.B. — Prolonged depression of cellular immunity in cured laryngo-pharyngeal cancer patients treated with radiation therapy.Cancer, 1975,35, 638–644.

    Article  PubMed  CAS  Google Scholar 

  55. TNM Classification des tumeurs malignes. 3e éd. UICC, Genève, 1979.

  56. VRABEC D.P. — Multiple primary malignancies of the upper aerodigestive system.Ann. Otol., 1979,88, 846–854.

    CAS  Google Scholar 

  57. WARREN S., GATES O. — Multiple primary malignant tumors; a survey of the literature and a statistical study.Amer. J. of cancer, 1932,16, 1358–1414.

    Google Scholar 

  58. WEISS W. — Cigarette smoke as a carcinogen.Amer. Rev. resp. Dis., 1973,108, 364.

    PubMed  CAS  Google Scholar 

  59. WYNDER E.L., DODO H., BLOCH D.A., GANTT R.C., MOORE O.S. — Epidemiologic investigation of multiple primary cancer of the upper alimentary and respiratory tracts. I. A retrospective study.Cancer, 1969,24, 730–739.

    Article  PubMed  CAS  Google Scholar 

  60. WYNDER E.L., MUSHINSKI M., SPIVAK J. — Tobacco and alcohol consumption in relation to the development of multiple primary cancers.Cancer, 1977,40, 1872–1878.

    Article  PubMed  CAS  Google Scholar 

  61. YAMADA A., KOBAYASHI S., KAWAI B., FUJIMOTO A., NAKAYAMA K. — Study on X-ray findings of early oesophageal cancer.Aust. Radiol., 1972,16, 238–246.

    Article  CAS  Google Scholar 

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  1. Service O.R.L., Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, (Suisse)

    R. Pasche, M. Savary & P. Monnier

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Pasche, R., Savary, M. & Monnier, P. Multifocalité du carcinome épidermoïde sur les voies digestive supérieure et respiratoire distale: technicité du diagnostic endoscopique. Acta Endosc 11, 277–291 (1981). https://doi.org/10.1007/BF02970387

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